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Melanoma: New Mechanism of Treatment Resistance

Researchers were able to increase sensitivity to vemurafinib in resistant melanoma cell lines by reactivating genes that are involved in cell division.

Poor Sleep Quality, Symptom Burden

Patients who slept poorly exhibited greater symptom burden and overall mood disturbance.

Sleep Cycle, Causal Factor of CML

If these findings are confirmed, 1 logical policy initiative would be to limit rotating night shifts to less than 20 years in total.

Patient Assistance Programs, Rising Drug Prices

The federal government is investigating some drugmakers' relationships with the charities that run assistance programs.

ABCB1 Expression, Imatinib Response in CML

Increase in ABCB1 mRNA expression may serve as a marker for patients likely to be resistant to imatinib.

Endocrine Therapy Continuation Beyond 5 Years?

Using case studies, experts discuss the Breast Cancer Index<sup>SM</sup> as a tool for clinicians and patients considering extended adjuvant endocrine therapy for early-stage ER+ breast cancer.

A New Collaboration to Cure Melanoma

In the not-too-distant future, several new combination therapies are expected, and they should represent an improvement not only in effectiveness, but in safety as well.

New Video Series: High-Risk Hodgkin Lymphoma

Patrick J. Stiff, MD of the Cardinal Bernardin Cancer Center in Maywood, Illinois

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Viewpoints

New Mechanism of Treatment Resistance in BRAF-Mutant Melanoma Identified

New Mechanism of Treatment Resistance in BRAF-Mutant Melanoma Identified

Researchers were able to increase sensitivity to vemurafinib in resistant melanoma cell lines by reactivating genes that are involved in cell division.

Poor Sleep Quality Associated With Symptom Burden Among Phase 1 Trial Participants

Poor Sleep Quality Associated With Symptom Burden Among Phase 1 Trial Participants

Patients who slept poorly exhibited greater symptom burden and overall mood disturbance.

Feature Articles

PAP Series: Patient Assistance Programs "Culprits" of Rising Drug Prices

PAP Series: Patient Assistance Programs "Culprits" of Rising Drug Prices

The federal government is investigating some drugmakers' relationships with the charities that run assistance programs.

ABCB1 Expression Associated With Response to Imatinib in Chronic Myeloid Leukemia

ABCB1 Expression Associated With Response to Imatinib in Chronic Myeloid Leukemia

Increase in ABCB1 mRNA expression may serve as a marker for patients likely to be resistant to imatinib.

Should We Abandon PSA Testing Or Make it More Targeted?

Should We Abandon PSA Testing Or Make it More Targeted?

Widespread contamination of the Prostate, Lung, Colorectal, and Ovary (PLCO) Cancer Screening Trial has reignited the debate around prostate-specific antigen testing.

Age and Acute Myeloid Leukemia: A Review of Current Literature

Age and Acute Myeloid Leukemia: A Review of Current Literature

Dr Isabel Cunningham reviews and highlights important, recently published articles with recommendations for treating elderly patients with acute myeloid leukemia (AML).

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