POPULAR SECTIONS

TREATMENT REGIMENS DRUG INFO MEDICAL CALCULATORS PUBLISHERS ALLIANCE VIDEOS CME

Biomarker Can Help Identify Pleural Mesothelioma

Share this article:
Biomarker Can Help Identify Pleural Mesothelioma
Biomarker Can Help Identify Pleural Mesothelioma

(HealthDay News) -- Fibulin-3 levels in plasma and lung fluids can discriminate patients with mesothelioma from others with asbestos exposure or those whose lung effusions are unrelated to mesothelioma, according to a study published in the Oct. 11 issue of the New England Journal of Medicine.

Harvey I. Pass, M.D., from the New York University Langone Medical Center in New York City, and colleagues examined whether fibulin-3 levels in plasma were a good biomarker for pleural mesothelioma in 92 patients with mesothelioma, 136 asbestos-exposed persons without cancer, 93 patients with effusions not due to mesothelioma, and 43 healthy controls. Fibulin-3 levels were also measured in effusions (from 74 patients with mesothelioma, 39 with benign effusions, and 54 with malignant effusions not related to mesothelioma) or in both plasma and effusions.

The researchers found that plasma fibulin-3 levels were significantly higher in patients with pleural mesothelioma than in asbestos-exposed persons without mesothelioma. In pleural effusions, fibulin-3 levels were significantly higher in patients with pleural mesothelioma than in patients with effusions not due to mesothelioma. Further validation showed fibulin-3 staining in 100 percent of 26 tumor samples. In comparing patients with and without mesothelioma, plasma fibulin-3 levels had a sensitivity of 96.7 percent and a specificity of 95.5 percent at a cut-off of 52.8 ng/mL fibulin-3. On blinded validation of a sample of plasma specimens from 96 asbestos-exposed patients and 48 patients with mesothelioma, the area under the curve was 0.87.

"The results of our study suggest that levels of fibulin-3 in plasma and effusions may aid in determining the diagnosis and prognosis of pleural mesothelioma," Pass and colleagues conclude.

Several authors disclosed financial conflicts of interest, including mesothelioma-related expert testimony, patents, and ties to the biotechnology and pharmaceutical industries.

Full Text (subscription or payment may be required)

Share this article:

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Community Poll

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs

More in Lung Cancer

Patients with Lung and Colorectal Cancer Report Unmet Needs for Symptom Management

Patients with Lung and Colorectal Cancer Report Unmet ...

Newly diagnosed patients with lung and colorectal cancer indicate unmet needs for symptom management.

Clinical Decision Support Technology Improves Symptom Management for Patients with Lung Cancer

Clinical Decision Support Technology Improves Symptom Management for ...

Clinical decision support using symptom assessment and management intervention improved lung cancer outcomes.

For Patients With Advanced Non-Small Cell Lung Cancer (NSCLC), Dacomitinib Not Superior to Erlotinib

For Patients With Advanced Non-Small Cell Lung Cancer ...

Researchers have found that dacomitinib was not superior to erlotinib in patients with advanced non-small cell lung cancer (NSCLC).