Bladder Cancer Treatment Is Being Revolutionized by Immunotherapy

Share this content:
Clinical trials and drug approvals in the past several years have dramatically improved bladder cancer treatment.
Clinical trials and drug approvals in the past several years have dramatically improved bladder cancer treatment.

Recent approvals by the US Food and Drug Administration (FDA) and ongoing clinical trials of immunotherapies for metastatic bladder cancer enabled improvements in clinical care for the first time in decades. In 2016, for example, the PD-L1 inhibitor atezolizumab was approved for metastatic urothelial carcinoma (mUC), followed in 2017 by the approval of the PD-1 inhibitor, nivolumab, for the same indication.

“Evidence that inhibition of the PD-1/PD-L1 pathway has clinical activity in patients with mUC opened the door to the investigation of additional immune therapies, either as single agents or in combination with a broad array of agents, in an effort to increase the number of patients who respond to T cell checkpoint blockade,” explained the authors of a recent review published in Current Opinion in Oncology.1

Around a third of patients with urothelial carcinoma present with muscle-invasive disease (T2-T4a), a staging with poor prognosis likely due to occult metastases. Metastatic disease is incurable and is treated with cisplatin-based combination systemic therapy, though many patients are ineligible for this treatment due to renal insufficiency.

PD-1 and PD-L1 checkpoint inhibitors have, however, yielded durable clinical responses in subgroups of previously treated and treatment-naïve patients with mUC.

RELATED: Bladder Cancer: Genomics May Predict Benefit from Neoadjuvant Chemotherapy

Immunotherapy combinations such as PD-1 inhibition and cytotoxic T-lymphocyte antigen 4 (CTLA-4) inhibition (eg ipilimumab) also show promising results in improved response rates in urothelial carcinoma.

Page 1 of 2

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters