21-Gene Assay Associated with Significant Change in Treatment Decisions
the Cancer Therapy Advisor take:
Physicians were more likely to change treatment decisions after evaluating patients using the 21-gene Oncotype DX Assay, according to an article published online in the journal The Oncologist.
Ninety-five patients with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative early-stage breast cancer (ECB), and node-negative (pN0) disease or micrometastases in up to three lymph nodes (pN1mi) were evaluated regarding their cancer treatments.
Results showed that treatment regimen recommendations changed in 37% of patients, primarily from chemoendocrine to strictly endocrine treatment. The proportion of patients recommended to undergo chemotherapy treatment was also found to decrease from pretest to post-test (52% to 25%, respectively).
After receiving the Oncotype Recurrence Score result, 61% of patients who were originally recommended chemotherapy treatment were newly advised to receive endocrine treatment alone.
Furthermore, physicians’ confidence significantly improved after receiving the Recurrence Score value.
The authors noted that Oncotype DX testing is associated with an overall reduction in chemotherapy use as treatment in patients with ER+, human epidermal growth factor receptor 2-negative EBC, which was consistent with previous studies.
Physicians were more likely to change treatment decisions after evaluating patients using the 21-gene Oncotype DX Assay.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- Resveratrol and Cancer
- Liquid Biopsies and Cancer Detection: New Test Assesses Levels of Circulating Proteins for Early-Stage Diagnosis
- Understanding Telomerase: Higher Quality Images Give Insight Into Developing New Agents for Inhibition
- ARID1A Mutations Might Predict Tumor Response to Immunotherapy
- Global Burden of Myeloma Increasing, Access to Treatments Lacking
- Longer Overall Survival with FOLFIRINOX Versus Gemcitabine/nab-Paclitaxel in Pancreatic Cancer
- Dendritic Cell Vaccine Plus Salvage Chemotherapy Active in Gastric Cancer
- Autophagy-Related Proteins May Be Prognostic Factors for CRC Survival With Chemotherapy
- Real-World Regorafenib Outcomes Mirror Clinical Trial Results in Metastatic Colorectal Cancer
- Identifying Potential Targets for Companion Diagnostic Tests Using Poly-Ligand Profiling