21-Gene Assay Associated with Significant Change in Treatment Decisions
the Cancer Therapy Advisor take:
Physicians were more likely to change treatment decisions after evaluating patients using the 21-gene Oncotype DX Assay, according to an article published online in the journal The Oncologist.
Ninety-five patients with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative early-stage breast cancer (ECB), and node-negative (pN0) disease or micrometastases in up to three lymph nodes (pN1mi) were evaluated regarding their cancer treatments.
Results showed that treatment regimen recommendations changed in 37% of patients, primarily from chemoendocrine to strictly endocrine treatment. The proportion of patients recommended to undergo chemotherapy treatment was also found to decrease from pretest to post-test (52% to 25%, respectively).
After receiving the Oncotype Recurrence Score result, 61% of patients who were originally recommended chemotherapy treatment were newly advised to receive endocrine treatment alone.
Furthermore, physicians’ confidence significantly improved after receiving the Recurrence Score value.
The authors noted that Oncotype DX testing is associated with an overall reduction in chemotherapy use as treatment in patients with ER+, human epidermal growth factor receptor 2-negative EBC, which was consistent with previous studies.
Physicians were more likely to change treatment decisions after evaluating patients using the 21-gene Oncotype DX Assay.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- Do Oral Contraceptives Actually Increase Breast Cancer Risk?
- Pancreatitis and the Risk of Cancer
- FDA Approves Olaparib for BRCA-Positive Breast Cancer
- Hyperthermic Intraperitoneal Chemotherapy With Cytoreductive Surgery Prolongs OS in Gastric Cancer
- RAMIE May Improve Post-operative Outcomes Among Patients With Esophageal Cancer
- Alcohol Consumption and Cancer
- Pembrolizumab May Be Effective for Previously Treated Hepatocellular Carcinoma
- Cabozantinib May Improve Survival Outcomes in Relapsed Hepatocellular Carcinoma
- PEGPH20 Plus mFOLFIRINOX Worsens OS Among Patients With Pancreatic Cancer
- Gemcitabine Plus S-1 May Be Non-inferior to Standard Therapy for Biliary Tract Cancer