For Ductal Carcinoma In-Situ, Endocrine Therapy Improves Event-Free Survival

Share this content:
Endocrine therapy use in ductal carcinoma in situ treated with conserving surgery plus radiotherapy associated with improved event-free survival.
Endocrine therapy use in ductal carcinoma in situ treated with conserving surgery plus radiotherapy associated with improved event-free survival.

Endocrine therapy use in patients with ductal carcinoma in situ treated with conserving surgery plus radiotherapy was associated with improved event-free survival, thereby confirming the generalizability of the 1999 National Surgical Adjuvant Breast and Bowel Project (NSABP)-B24 trial, a population-based analysis published online ahead of print in the journal Annals of Oncology has shown.

The NSABP-B24 trial showed that tamoxifen decreased the risk of relapse in women with ductal carcinoma in-situ treated with breast conserving surgery and radiotherapy, but a subgroup analysis demonstrated that tamoxifen mostly benefited those with estrogen receptor-positive disease.

For this population-based analysis, researchers identified 417 patients who underwent surgery and radiotherapy before the NSABP-B24 study and 1,548 who underwent the same treatment after the study, who were further divided into those who received treatment before or after the subgroup analysis.

Results showed that 20% of the 2,061 patients received endocrine therapy. Researchers found that the proportion of patients who received endocrine therapy increased from 0.2% before the NSABP-B24 trial to 26% after the trial.

RELATED: Neratinib Improves Two-Year Survival in Breast Cancer After Adjuvant Chemo, Trastuzumab

The study also demonstrated that estrogen receptor-positive disease and younger age were associated with increased use of endocrine therapy, and endocrine therapy was associated with improved event-free survival (HR = 0.6; P=0.02).

The findings suggest that the results of the NSABP-B24 trial are generalizable at a population level.

Reference

  1. Lo AC, Truong PT, Wai ES, et al. Population-based analysis of the impact and generalizability of the NSABP-B24 study on endocrine therapy for patients with ductal carcinoma in situ of the breast. Ann Oncol. 2015. [Epub ahead of print]. doi: 10.1093/annonc/mdv251.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters