Insulin Resistance Raises Breast Cancer Risk Regardless of Weight

Share this content:
Study of postmenopausal women suggests hormone levels matter more than excess weight in breast cancer risk.
Study of postmenopausal women suggests hormone levels matter more than excess weight in breast cancer risk.

After menopause, unhealthy insulin levels may predict breast cancer risk even more than excess weight, new research suggests. The study was published in Cancer Research.

To assess insulin's role in breast cancer risk, Marc Gunter, Ph.D., an associate professor of cancer epidemiology and prevention at the Imperial College London School of Public Health, and colleagues studied 3,327 women without diabetes, 497 of whom developed breast cancer over eight years. The authors analyzed information on their weight, fasting insulin levels, and insulin resistance.

The researchers found that high fasting insulin levels doubled the risk of breast cancer, both for overweight and normal-weight women. In addition, women who were overweight and insulin-resistant had an 84 percent greater risk of breast cancer than overweight women who weren't insulin-resistant.

RELATED: Breast Cancer Prognosis Impacted by Race, Ethnicity

"The women who are overweight but who do not have metabolic abnormalities (as assessed by insulin resistance) are not at increased risk of breast cancer compared to normal-weight women," Gunter told HealthDay. "On the other hand, normal-weight women with metabolic abnormalities were at approximately the same elevated risk of breast cancer as overweight women with metabolic abnormalities."

The new findings suggest "that it is metabolic health, and not overweight per se, that is associated with increased risk of breast cancer in postmenopausal women," he said.

Reference

  1. Gunter, Marc J., et al. "Breast Cancer Risk in Metabolically Healthy but Overweight Postmenopausal Women." Cancer Research. doi: 10.1158/0008-5472.CAN-14-2317. January 15, 2015.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters