Dasatinib Discontinuation After 1 Year Feasible in Certain Patients With CML

Share this content:
Dasatinib discontinuation after sustained deep molecular response for more than 1 year is feasible in patients with chronic myeloid leukemia.
Dasatinib discontinuation after sustained deep molecular response for more than 1 year is feasible in patients with chronic myeloid leukemia.

Dasatinib discontinuation after sustained deep molecular response for more than 1 year is feasible in patients with chronic myeloid leukemia (CML), a new study published online ahead of print in the journal The Lancet Haematology has shown.1

Because first-line imatinib can be successfully discontinued in patients with CML after deep molecular response has been sustained for at least 2 years, researchers in Japan sought to evaluate the safety and efficacy of discontinuing second-line or subsequent dasatinib after at least 1 year of deep molecular response.

For the prospective, multicenter, Dasatinib Discontinuation trial, researchers enrolled 88 patients receiving dasatinib consolidation therapy with confirmed deep molecular response for at least 1 year.

Of those, 63 discontinued therapy and were followed up with every month in year 1, every 3 months in year 2, and every 6 months in year 3 to assess deep molecular response and immunological profiles.

Results showed that after a median follow-up of 20 months, 30 of the 63 patients maintained deep molecular response while 33 patients experienced molecular relapses within 7 months after discontinuation. The other 25 patients who were excluded from discontinuation continued to receive treatment and none experienced disease progression.

The study demonstrated an overall treatment-free remission of 49% (95% CI, 36 - 61) at 6 months.

RELATED: Postsurgical RCC Surveillance: Mayo Team Proposes a New Risk-based Approach

In regard to safety, no severe treatment-related toxicities were observed.

The 33 patients who relapsed restarted treatment and rapid molecular response was achieved in all 33, of whom 88% regained deep molecular response within 3 months. The other 4 achieved deep molecular response by 6 months.

Reference

  1. Imagawa J, Tanaka H, Okada M, et al. Discontinuation of dasatinib in patients with chronic myeloid leukaemia who have maintained deep molecular response for longer than 1 year (DADI trial): a multicentre phase 2 trial [published online ahead of print November 9, 2015]. Lancet Haematol. doi: 10.1016/S2352-3026(15)00196-9.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters