Drugs Contraindicated in Pregnancy

DRUGS CONTRAINDICATED IN PREGNANCY

This chart represents information on select drugs
that are contraindicated (Pregnancy category X) for
women who are pregnant. This is not an inclusive
list of products that carry that pregnancy category.
Those drugs that are contraindicated at a certain
phase of the pregnancy are listed next to the product
name. For more information on specific drug
monographs, see product entries or consult the
manufacturer.

Allergic Disorders

Vistaril (hydroxyzine) Early pregnancy

 

Cardiovascular System

Advicor (niacin ext-rel/lovastatin)

Aggrenox (dipyridamole/aspirin) 3rd trimester

Altoprev (lovastatin)

Bayer (aspirin) 3rd trimester

Caduet (amlodipine/atorvastatin)

Coumadin (warfarin sodium)

Crestor (rosuvastatin)

Ecotrin (aspirin) 3rd trimester

Lescol (fluvastatin)

Lescol XL (fluvastatin)

Letairis (ambrisentan)

Lipitor (atorvastatin)

Livalo (pitavastatin)

Lovastatin tabs

Multaq (dronedarone)

Pravachol (pravastatin)

Simcor (niacin ext-rel/simvastatin)

Tracleer (bosentan)

Vytorin (ezetimibe/simvastatin)

Zocor (simvastatin)

 

Central Nervous System

Beyaz (drospirenone/ethinyl estradiol)

Doral (quazepam)

Estazolam

Flurazepam

Halcion (triazolam)

Restoril (temazepam)

Vistaril (hydroxyzine) Early pregnancy

Yaz (drospirenone/ethinyl estradiol)

 

Dermatological Disorders

Amnesteem (isotretinoin)

Avage (tazarotene)

Beyaz (drospirenone/ethinyl estradiol)

Carac (fluorouracil)

Claravis (isotretinoin)

Efudex (fluorouracil)

Estrostep Fe (norethindrone acetate/ethinyl estradiol)

Fluoroplex (fluorouracil)

Loryna (drospirenone/ethinyl estradiol)

Ortho Tri-Cyclen 28 (norgestimate/ethinyl estradiol)

Propecia (finasteride)

Silvadene (silver sulfadiazine) Late pregnancy

Solaraze (diclofenac sodium) 3rd trimester

Soriatane (acitretin)

Sotret (isotretinoin)

SSD (silver sulfadiazine) Late pregnancy

SSD AF (silver sulfadiazine) Late pregnancy

Tazorac (tazarotene)

Tilia Fe (norethindrone acetate/ethinyl estradiol)

Tri-Legest Fe (norethindrone acetate/ethinyl estradiol)

Tri-previfem (norgestimate/ethinyl estradiol)

Tri-sprintec (norgestimate/ethinyl estradiol)

Yaz (drospirenone/ethinyl estradiol)

 

Endocrine Disorders

Androderm (testosterone)

Androgel (testosterone)

Android (methyltestosterone)

Axiron (testosterone)

Delatestryl (testosterone enanthate)

Depo-testosterone (testosterone cypionate)

Egrifta (tesamorelin)

Fluoxymesterone

Fortesta (testosterone)

Lupron (leuprolide acetate)

Methitest (methyltestosterone)

Oxandrin (oxandrolone)

Striant (testosterone)

Supprelin LA (histrelin acetate)

Synarel (nafarelin)

Testim (testosterone)

Testred (methyltestosterone)

 

Gastrointestinal Tract

Cytotec (misoprostol)

 

Infections & Infestations

Bactrim (sulfamethoxazole/trimethoprim) 3rd trimester

Copegus (ribavirin)

Flagyl (metronidazole) 1st trimester for trichomoniasis

Furadantin (nitrofurantoin) Pregnancy at term

Gantrisin (sulfisoxazole) 3rd trimester

Grifulvin V (griseofulvin)

Gris-Peg (griseofulvin)

Macrobid (nitrofurantoin as macrocrystals and monohydrate) Pregnancy at term

Macrodantin (nitrofurantoin macrocrystals) Pregnancy at term

Rebetol (ribavirin)

Rebetron (ribavirin/interferon alfa -2b)

Septra (sulfamethoxazole/trimethoprim) 3rd trimester

Sulfadiazine Pregnancy at term

Tindamax (tinidazole) 1st trimester

Urobiotic-250 (oxytetracycline HCl/sulfamethizole/ phenazopyridine) Late pregnancy

Virazole (ribavirin)

 

Metabolic Disorders

Zavesca (miglustat)

 

Musculoskeletal Disorders

Advil (ibuprofen) 3rd trimester

Aleve (naproxen sodium) 3rd trimester

Ansaid (flurbiprofen) Late pregnancy

Arava (leflunomide)

Arthrotec (diclofenac sodium/misoprostol)

Bayer (aspirin) 3rd trimester

BC Arthritis Strength (aspirin/caffeine/salicylamide) 3rd trimester

Carisoprodol/aspirin/codeine 3rd trimester

Cataflam (diclofenac potassium) Late pregnancy

Celebrex (celecoxib) 3rd trimester

Choline magnesium trisalicylate Pregnancy at term

Dantrium (dantrolene)

Daypro (oxaprozin) 3rd trimester

Diclofenac sodium Late pregnancy

Diflunisal 3rd trimester

Duexis (ibuprofen/famotidine) Late pregnancy (≥30wks)

Musculoskeletal Disorders (continued)

Ecotrin (aspirin) 3rd trimester

Etodolac Late pregnancy

Evista (raloxifene HCl)

Feldene (piroxicam) Late pregnancy

Ibuprofen 3rd trimester

Ketoprofen Late pregnancy

Mobic (meloxicam) 3rd trimester

Nabumetone 3rd trimester

Nalfon (fenoprofen calcium) 3rd trimester

Naprelan (naproxen) 3rd trimester

Probenecid + Colchicine

Prolia (denosumab)

Rheumatrex (methotrexate sodium)

Salsalate 3rd trimester

Vimovo (naproxen/esomeprazole) Late pregnancy (≥30wks)

Zipsor (diclofenac potassium) Late pregnancy

 

Neoplasms

Bexxar (tositumomab)

Casodex (bicalutamide)

Delestrogen (estradiol valerate)

Efudex (fluorouracil)

Eligard (leuprolide acetate)

Estrace (estradiol)

Evista (raloxifene HCl)

Firmagon (degarelix)

Fluoxymesterone

Menest (esterified estrogens)

Revlimid (lenalidomide)

Targretin (bexarotene)

Thalomid (thalidomide)

Trelstar (triptorelan pamoate)

Trexall (methotrexate)

Vantas (histrelin acetate)

Zytiga (abiraterone acetate)

 

Nutrition

Didrex (benzphetamine)

Fosteum (genistein/citrated zinc/cholecalciferol)

Megace ES (megestrol acetate)

Megace Suspension (megestrol acetate)

Xenical (orlistat)

 

Ob/Gyn

ALL ORAL CONTRACEPTIVES

ALL HORMONE REPLACEMENT THERAPY

Advil (ibuprofen) 3rd trimester

Aleve (naproxen sodium) 3rd trimester

Aygestin (norethindrone acetate)

Betadine douche (povidone-iodine)

Bravelle (urofollitropin)

Cataflam (diclofenac potassium) Late pregnancy

Celebrex (celecoxib) 3rd trimester

Cetrotide (cetrorelix)

Clomid (clomiphene citrate)

Depo-subQ provera (medroxyprogesterone acetate)

Endometrin (micronized progesterone) Ectopic pregnancy

Flagyl (metronidazole) 1st trimester for trichomoniasis

Follistim (follitropin beta)

Ganirelix acetate

Gonal-F (follitropin alfa)

Ibuprofen 3rd trimester

Lupron Depot (leuprolide acetate)

Menopur (menoptropins)

Methergine (methylergonovine)

Midol teen (acetaminophen/pamabrom) 3rd trimester

Mifeprex (mifepristone)

Naprelan (naproxen) 3rd trimester

Ovidrel (choriogonadotropin alfa)

Ponstel (mefenamic acid) Late pregnancy

Repronex 75 IU (follicle-stimulating hormone/luteinizing hormone)

Serophene (clomiphene citrate)

Synarel (nafarelin acetate)

Tindamax (tinidazole) 1st trimester

Zoladex (goserelin)

 

Pain Management

Advil (ibuprofen) 3rd trimester

Advil Migraine (ibuprofen) 3rd trimester

Aleve (naproxen sodium) 3rd trimester

Bayer (aspirin) 3rd trimester

BC Original Formula (aspirin/caffeine/salicylamide) 3rd trimester

Caldolor (ibuprofen) 3rd trimester

Cataflam (diclofenac potassium) Late pregnancy

Celebrex (celecoxib) 3rd trimester

Choline magnesium trisalicylate Pregnancy at term

D.H.E. 45 (dihydroergotamine mesylate)

Diflunisal 3rd trimester

Ergotamine tartrate/caffeine

Etodolac Late pregnancy

Excedrin Migraine (acetaminophen/aspirin/ caffeine) 3rd trimester

Fiorinal (butalbital/aspirin/caffeine) 3rd trimester

Fiorinal w. Codeine (butalbital/aspirin/caffeine/ codeine phosphate) 3rd trimester

Ibudone (hydrocodone bitartrate/ibuprofen) 3rd trimester

Ketorolac Late pregnancy

Migranal (dihydroergotamine mesylate)

Motrin Migraine Pain (ibuprofen) 3rd trimester

Nalfon (fenoprofen calcium) 3rd trimester

Naprelan (naproxen) 3rd trimester

Percodan (oxycodone HCl/aspirin) 3rd trimester

Ponstel (mefenamic acid) Late pregnancy

Synalgos-DC (dihydrocodeine bitartrate/aspirin/caffeine) 3rd trimester

Vicoprofen (hydrocodone bitartrate/ibuprofen) 3rd trimester

 

Respiratory Tract

None available

 

Urogenital System

Avodart (dutasteride HCl) AVOID HANDLING CAPSULES

Caverject (alprostadil)

Edex (alprostadil)

Jalyn (dutasteride/tamsulosin HCl)

Lithostat (acetohydroxamic acid)

Proscar (finasteride) AVOID HANDLING CRUSHED/BROKEN TABLETS

 

Allergic Disorders

Vistaril (hydroxyzine) Early pregnancy

 

Cardiovascular System

Advicor (niacin ext-rel/lovastatin)

Aggrenox (dipyridamole/aspirin) 3rd trimester

Altoprev (lovastatin)

Bayer (aspirin) 3rd trimester

Caduet (amlodipine/atorvastatin)

Coumadin (warfarin sodium)

Crestor (rosuvastatin)

Ecotrin (aspirin) 3rd trimester

Lescol (fluvastatin)

Lescol XL (fluvastatin)

Letairis (ambrisentan)

Lipitor (atorvastatin)

Livalo (pitavastatin)

Lovastatin tabs

Multaq (dronedarone)

Pravachol (pravastatin)

Simcor (niacin ext-rel/simvastatin)

Tracleer (bosentan)

Vytorin (ezetimibe/simvastatin)

Zocor (simvastatin)

 

Central Nervous System

Beyaz (drospirenone/ethinyl estradiol)

Doral (quazepam)

Estazolam

Flurazepam

Halcion (triazolam)

Restoril (temazepam)

Vistaril (hydroxyzine) Early pregnancy

Yaz (drospirenone/ethinyl estradiol)

 

Dermatological Disorders

Amnesteem (isotretinoin)

Avage (tazarotene)

Beyaz (drospirenone/ethinyl estradiol)

Carac (fluorouracil)

Claravis (isotretinoin)

Efudex (fluorouracil)

Estrostep Fe (norethindrone acetate/ethinyl estradiol)

Fluoroplex (fluorouracil)

Loryna (drospirenone/ethinyl estradiol)

Ortho Tri-Cyclen 28 (norgestimate/ethinyl estradiol)

Propecia (finasteride)

Silvadene (silver sulfadiazine) Late pregnancy

Solaraze (diclofenac sodium) 3rd trimester

Soriatane (acitretin)

Sotret (isotretinoin)

SSD (silver sulfadiazine) Late pregnancy

SSD AF (silver sulfadiazine) Late pregnancy

Tazorac (tazarotene)

Tilia Fe (norethindrone acetate/ethinyl estradiol)

Tri-Legest Fe (norethindrone acetate/ethinyl estradiol)

Tri-previfem (norgestimate/ethinyl estradiol)

Tri-sprintec (norgestimate/ethinyl estradiol)

Yaz (drospirenone/ethinyl estradiol)

 

Endocrine Disorders

Androderm (testosterone)

Androgel (testosterone)

Android (methyltestosterone)

Axiron (testosterone)

Delatestryl (testosterone enanthate)

Depo-testosterone (testosterone cypionate)

Egrifta (tesamorelin)

Fluoxymesterone

Fortesta (testosterone)

Lupron (leuprolide acetate)

Methitest (methyltestosterone)

Oxandrin (oxandrolone)

Striant (testosterone)

Supprelin LA (histrelin acetate)

Synarel (nafarelin)

Testim (testosterone)

Testred (methyltestosterone)

 

Gastrointestinal Tract

Cytotec (misoprostol)

 

Infections & Infestations

Bactrim (sulfamethoxazole/trimethoprim) 3rd trimester

Copegus (ribavirin)

Flagyl (metronidazole) 1st trimester for trichomoniasis

Furadantin (nitrofurantoin) Pregnancy at term

Gantrisin (sulfisoxazole) 3rd trimester

Grifulvin V (griseofulvin)

Gris-Peg (griseofulvin)

Macrobid (nitrofurantoin as macrocrystals and monohydrate) Pregnancy at term

Macrodantin (nitrofurantoin macrocrystals) Pregnancy at term

Rebetol (ribavirin)

Rebetron (ribavirin/interferon alfa -2b)

Septra (sulfamethoxazole/trimethoprim) 3rd trimester

Sulfadiazine Pregnancy at term

Tindamax (tinidazole) 1st trimester

Urobiotic-250 (oxytetracycline HCl/sulfamethizole/ phenazopyridine) Late pregnancy

Virazole (ribavirin)

 

Metabolic Disorders

Zavesca (miglustat)

 

Musculoskeletal Disorders

Advil (ibuprofen) 3rd trimester

Aleve (naproxen sodium) 3rd trimester

Ansaid (flurbiprofen) Late pregnancy

Arava (leflunomide)

Arthrotec (diclofenac sodium/misoprostol)

Bayer (aspirin) 3rd trimester

BC Arthritis Strength (aspirin/caffeine/salicylamide) 3rd trimester

Carisoprodol/aspirin/codeine 3rd trimester

Cataflam (diclofenac potassium) Late pregnancy

Celebrex (celecoxib) 3rd trimester

Choline magnesium trisalicylate Pregnancy at term

Dantrium (dantrolene)

Daypro (oxaprozin) 3rd trimester

Diclofenac sodium Late pregnancy

Diflunisal 3rd trimester

Duexis (ibuprofen/famotidine) Late pregnancy (≥30wks)

Ecotrin (aspirin) 3rd trimester

Etodolac Late pregnancy

Evista (raloxifene HCl)

Feldene (piroxicam) Late pregnancy

Ibuprofen 3rd trimester

Ketoprofen Late pregnancy

Mobic (meloxicam) 3rd trimester

Nabumetone 3rd trimester

Nalfon (fenoprofen calcium) 3rd trimester

Naprelan (naproxen) 3rd trimester

Probenecid + Colchicine

Prolia (denosumab)

Rheumatrex (methotrexate sodium)

Salsalate 3rd trimester

Vimovo (naproxen/esomeprazole) Late pregnancy (≥30wks)

Zipsor (diclofenac potassium) Late pregnancy

 

Neoplasms

Bexxar (tositumomab)

Casodex (bicalutamide)

Delestrogen (estradiol valerate)

Efudex (fluorouracil)

Eligard (leuprolide acetate)

Estrace (estradiol)

Evista (raloxifene HCl)

Firmagon (degarelix)

Fluoxymesterone

Menest (esterified estrogens)

Revlimid (lenalidomide)

Targretin (bexarotene)

Thalomid (thalidomide)

Trelstar (triptorelan pamoate)

Trexall (methotrexate)

Vantas (histrelin acetate)

Zytiga (abiraterone acetate)

 

Nutrition

Didrex (benzphetamine)

Fosteum (genistein/citrated zinc/cholecalciferol)

Megace ES (megestrol acetate)

Megace Suspension (megestrol acetate)

Xenical (orlistat)

 

Ob/Gyn

ALL ORAL CONTRACEPTIVES

ALL HORMONE REPLACEMENT THERAPY

Advil (ibuprofen) 3rd trimester

Aleve (naproxen sodium) 3rd trimester

Aygestin (norethindrone acetate)

Betadine douche (povidone-iodine)

Bravelle (urofollitropin)

Cataflam (diclofenac potassium) Late pregnancy

Celebrex (celecoxib) 3rd trimester

Cetrotide (cetrorelix)

Clomid (clomiphene citrate)

Depo-subQ provera (medroxyprogesterone acetate)

Endometrin (micronized progesterone) Ectopic pregnancy

Flagyl (metronidazole) 1st trimester for trichomoniasis

Follistim (follitropin beta)

Ganirelix acetate

Gonal-F (follitropin alfa)

Ibuprofen 3rd trimester

Lupron Depot (leuprolide acetate)

Menopur (menoptropins)

Methergine (methylergonovine)

Midol teen (acetaminophen/pamabrom) 3rd trimester

Mifeprex (mifepristone)

Naprelan (naproxen) 3rd trimester

Ovidrel (choriogonadotropin alfa)

Ponstel (mefenamic acid) Late pregnancy

Repronex 75 IU (follicle-stimulating hormone/luteinizing hormone)

Serophene (clomiphene citrate)

Synarel (nafarelin acetate)

Tindamax (tinidazole) 1st trimester

Zoladex (goserelin)

 

Pain Management

Advil (ibuprofen) 3rd trimester

Advil Migraine (ibuprofen) 3rd trimester

Aleve (naproxen sodium) 3rd trimester

Bayer (aspirin) 3rd trimester

BC Original Formula (aspirin/caffeine/salicylamide) 3rd trimester

Caldolor (ibuprofen) 3rd trimester

Cataflam (diclofenac potassium) Late pregnancy

Celebrex (celecoxib) 3rd trimester

Choline magnesium trisalicylate Pregnancy at term

D.H.E. 45 (dihydroergotamine mesylate)

Diflunisal 3rd trimester

Ergotamine tartrate/caffeine

Etodolac Late pregnancy

Excedrin Migraine (acetaminophen/aspirin/ caffeine) 3rd trimester

Fiorinal (butalbital/aspirin/caffeine) 3rd trimester

Fiorinal w. Codeine (butalbital/aspirin/caffeine/ codeine phosphate) 3rd trimester

Ibudone (hydrocodone bitartrate/ibuprofen) 3rd trimester

Ketorolac Late pregnancy

Migranal (dihydroergotamine mesylate)

Motrin Migraine Pain (ibuprofen) 3rd trimester

Nalfon (fenoprofen calcium) 3rd trimester

Naprelan (naproxen) 3rd trimester

Percodan (oxycodone HCl/aspirin) 3rd trimester

Ponstel (mefenamic acid) Late pregnancy

Synalgos-DC (dihydrocodeine bitartrate/aspirin/caffeine) 3rd trimester

Vicoprofen (hydrocodone bitartrate/ibuprofen) 3rd trimester

 

Respiratory Tract

None available

 

Urogenital System

Avodart (dutasteride HCl) AVOID HANDLING CAPSULES

Caverject (alprostadil)

Edex (alprostadil)

Jalyn (dutasteride/tamsulosin HCl)

Lithostat (acetohydroxamic acid)

Proscar (finasteride) AVOID HANDLING CRUSHED/BROKEN TABLETS

*Not an inclusive list.

(Rev. 7/2014)

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