Insulin Administration

INSULIN ADMINISTRATION
Prepar-
ation
Brand Route Adminis-
tration
Mixing Insulins Comments
RAPID-ACTING
Insulin Afrezza Rx oral
inh
At the beginning of a meal Loss of drug effect if inhaler is mishandled. See full labeling.
Insulin Aspart NovoLog Rx SC
CSII
IV
Within 5−10mins before a meal SC: May mix with NPH insulin. Draw NovoLog into syringe first. Inject immediately after mixing. May dilute with Insulin Diluting Medium for NovoLog to 1:10 (U‑10) or 1:2 (U‑50) concentrations.
CSII: Do not dilute or mix with other insulins
IV: Do not mix with other insulins
CSII: Change inj site at least every 3 days and reservoir at least every 6 days.
Insulin Glulisine Apidra Rx SC
CSII
IV
Within 15mins before a meal or 20mins after starting a meal SC: May mix with NPH insulin. Draw Apidra into syringe first. Inject immediately after mixing.
CSII: Do not dilute or mix with other insulins
IV: Do not mix with other insulins
CSII: Change inj site at least every 48hrs and reservoir at least every 2 days.
Insulin Lispro Humalog Rx SC
CSII
Within 15mins before or immedi-
ately after a meal
SC: May mix with Humulin N. Draw Humalog into syringe first. Inject immediately after mixing. May dilute with STERILE DILUENT for Humalog to 1:10 (U‑10) or 1:2 (U‑50) concentrations.
CSII: Do not dilute or mix with other insulins
CSII: Change inj site at least every 3 days and reservoir at least every 7 days.
SHORT-ACTING
Insulin Injection Regular (R) Humulin
R U‑100
OTC SC
IM
IV*
Individ-
ualize
SC: May mix with longer-acting human insulins. Draw clear insulin into syringe first. Use syringes marked with U‑100.
Novolin R SC
IM
IV
≥3 times daily within 30mins before a meal
INTERMEDIATE-ACTING
Insulin Isophane Suspension (NPH) Humulin N OTC SC Individ-
ualize
May mix with Humalog or Humulin R. Draw clear insulin into syringe first then Humulin N. Rotate vial to mix. Should look uniformly cloudy. Use syringes marked with U‑100.
Novolin N May mix with other insulins. Draw clear insulin into syringe first then Novolin N. Rotate vial to mix. Should look uniformly cloudy. Use syringes marked with U‑100 or U‑40. Inject rapidly over 2−4secs to avoid clogging needle tip.
SHORT- AND INTERMEDIATE-ACTING MIXTURES
Insulin Aspart Protamine/
Insulin Aspart
NovoLog
Mix 70/30
Rx SC Twice daily within 15mins before a meal Do not mix with other insulins Roll vial, prefilled syringe 10 times until uniformly cloudy.
Insulin Isophane Suspension (NPH)/ Regular Insulin (R) Humulin 70/30 OTC SC Individ-
ualize
See product label Rotate vial to mix. Should look uniformly cloudy. Use syringes marked with U‑100.
Novolin 70/30 Do not change the ratio by adding NPH or Regular insulin to the vial. Use separate insulin formulations (Novolin N and Novolin R). Rotate vial to mix. Should look uniformly cloudy. Use syringes marked with U‑100 or U‑40. Inject rapidly over 2−4secs to avoid clogging needle tip.
Insulin Lispro Protamine/
Insulin Lispro
Humalog 
Mix 50/50
Rx SC Within 15mins before a meal Do not mix with any other insulins Rotate vial to mix. Should look uniformly cloudy.
Humalog 
Mix 75/25
LONG-ACTING
Insulin Detemir Levemir Rx SC Once daily (PM) or twice daily (12hrs apart) Do not dilute or mix with other insulins Should look clear, colorless.
Insulin Glargine Lantus Rx SC Once daily at the same time every day Do not dilute or mix with other insulins Should look clear, colorless.
Toujeo
Insulin Injection Regular (R) Humulin
R U‑500
Rx SC Individ-
ualize
See product label Caution with dosage. Should look water-clear. Use tuberculin or similar insulin syringe.
NOTES

Key:  CSII = continuous subcutaneous insulin infusion

* IV to be used in a clinical setting under proper medical supervision.

Rate of insulin absorption, onset and duration of action may be affected by the injection site, blood supply, temperature, exercise, and other variables.

Caution with changes in strength, manufacturer, preparation, species of insulin source.

Not an inclusive list of medications and/or dosing instructions. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling.

(Rev. 5/2015)

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