Critical Care Medicine
Primary Postpartum Hemorrhage (PPH)
Postpartum hemorrhagic shock
1. Description of the problem
PPH is described as excessive bleeding after 20 weeks of gestation -- that is, greater than 500 mL for a vaginal delivery and greater than 1 liter for a cesarean delivery.
PPH is defined as occurring within 24 hours after a vaginal or cesarean delivery.
Secondary postpartum hemorrhage occurs between 24 hours and 12 weeks after delivery.
Postpartum bleeding, regardless of the exact amount of bleeding, that causes maternal hemodynamic instability.
Most commonly, bleeding occurs in the 3rd stage of labor between delivery of the fetus and delivery of the placenta.
Usual signs of tachycardia and hypotension associated with severe bleeding may be masked or occur late because of the relative hypervolemic state of pregnancy.
Concealed pelvic hematomas with ongoing blood loss may also be masked initially.
Risk factors for PPH secondary to uterine atony, the most common cause of PPH
previous episodes of PPH
prolonged 3rd stage of labor
halogenated anesthetic agents
magnesium sulfate infusions
Causes of lower genital tract lacerations
prolonged or tumultuous labor
uterine hyperstimulation with oxytocic agents
forceps delivery and instrumental deliveries
in utero for more than 30 to 60 minutes after delivery of the fetus
more likely with preterm deliveries of < 24 weeks gestation
secondary to placenta abnormalities including accreta, increta and percreta
more frequent in patients with prior cesarean incisions and with any prior operative procedures of the uterus
disseminated intravascular coagulation (DIC) associated with placental abruption or other placental abnormalities
intrauterine fetal death
acute fatty liver of pregnancy
amniotic fluid embolism syndrome
It is essential to recognize that because of the relative hypervolemic state associated with normal pregnancy, the compensatory reflex tachycardia and tachypnea associated with early hemorrhage may not be seen initially in pregnant women who have ongoing hemorrhage or who may have concealed hematomas with ongoing bleeding. A high index of suspicion should be used for all pregnant patients if there is a possibility of ongoing bleeding.
Massive blood loss can occur from the uterus because of the significantly increased blood flow to the uterus during pregnancy.
Higher mortality rates are seen in postpartum hemorrhage when expeditious and prompt treatment is delayed and/or blood loss is underestimated.
2. Emergency Management
General treatment measures
Expectant management of the 3rd stage of labor involves only gentle fundal massage. Active management of the 3rd stage of labor includes uterine fundal massage, use of an oxytocic drug, and gentle traction of the umbilical cord with countertraction of the uterus to facilitate delivery of the placenta.
Early and aggressive fluid resuscitation with isotonic solutions using the "3:1" rule with 300 mL of crystalloid fluid replacement for every 100 mL of blood loss. Ongoing blood cell replacement is indicated in those patients with ongoing blood loss and/or hemodynamic instability.
Rapid therapeutic response to initial fluid resuscitation indicates <20% of blood volume lost and no additional fluids or blood products are needed.
Transient response to initial fluid resuscitation indicates that 20 to 40% of the blood volume is lost. Hemodynamics initially respond to the fluid rescucitation but later there are worsening vital signs. Continue fluid resuscitation and consider blood transfusions.
If there is no or minimal response to initial fluid rescucitation, there is most likely ongoing severe hemorrhage with more than 40% of blood volume lost. Continue aggressive fluid and blood product replacement.
Locate the source of bleeding using ultrasound, CT scans, and angiographic radiographic techniques.
Blood product administration depending on the degree of bleeding and laboratory abnormalities
Packed red blood cells (PRBC)
Fresh frozen plasma (FFP) - give 6-10 units of FFP for every 10 units of PRBC transfusions
Platelet transfusions - give 10-12 units if the platelet count decreases to less than 50 x 10 9/L
Cryoprecipitate should be given if fibrogen levels are less than 100 mg/dL (1.0 g/L).
Specific first-tier treatment measures
Manual external uterine massage
Digital exploration of the uterus to look for retained placental fragments
Direct examination and palpation of the vaginal vault and cervix
Compression of the abdominal aorta against the vertebral column as a lifesaving temporizing maneuver
5 units IV bolus
add 20-40 units of oxytocin to 1 liter of fluids
10 units intramyometrially
0.2 mg intramuscularly (IM) every 2 to 4 hours
Ergonovine (Ergotrate maleate)
100-125 micrograms IM or intramyometrially every 2 to 4 hours
200 to 250 micrograms IM
total dose is 1.25 mg
250 micrograms IM or intramyometrially every 15 to 90 minutes
total dose is 2 mg
800 micrograms rectally or sublingually
Blood product administration
Packed red blood cell transfusions are required if there is:
maternal hemodynamic instability and/or the total blood loss is more than 2 liters
Transfuse crossmatched packed red blood cells or type-specific blood. Type O non-crossmatched blood may be indicated if there is a delay in obtaining type-specific blood.
FFP, platelet, and cryoprecipitate transfusions are given as indicated by laboratory values and the degree of hemorrhage.
Recombinant activated factor VII (rFVIIa) of 60 to 120 micrograms/kg intravenous bolus is recommended in cases of postpartum hemorrhage that has not responded to medical therapy and administration of blood products.
Uterine packing - remove in 24 to 36 hours
Selective arterial angiographic embolization and ligation of the ovarian, uterine, hypogastric, and/or internal iliac arteries
Balloon occlusion catheters of the hypogastric and iliac arteries
Uterine compression sutures
Surgical subtotal or total hysterectomy as definitive therapy for:
cases not amenable to medical or angiographic treatments
cases of uterine rupture
highest risk for postpartum hysterectomy are those who are multiparous, had a prior cesarean delivery, or had abnormal placentation.
Uterine atony - palpation of a large and boggy uterus
Vaginal and cervical lacerations - palpation and manual exploration of the vagina and cervix
Known placental abnormalities including abruption, previa, accreta, percreta, and increta
Decrease in the baseline hematocrit greater than 10%
May not show typical signs of tachycardia and hypotension because of pregnancy-related hypervolemia until the blood loss exceeds 1500 mL
Occult bleeding occurs most frequently with retained placental products, uterine atony, and concealed hematomas in the pelvis, perineum, or retroperitoneal space. Should suspect occult concealed bleeding in patients in the 3rd stage of labor with hemodynamic instability but no signs of external bleeding.
Bedside ultrasonography can be used for the detection of clots, hematomas, and retained placental products.
Angiographic techniques can be both diagnostic and therapeutic by identifying the location of the bleed and subsequent treatment by ligation or with balloon occlusion of a specific artery.
Physical examination of the mother's uterus and lower genital tract and placenta and close monitoring of maternal vital signs is indicated after all vaginal and cesarean deliveries.
If occult bleeding is suspected, laboratory assessment following hemoglobin, hematocrit, and coagulation studies should be performed at regular intervals.
Most cases are straightforward with obvious external and visible vaginal bleeding that is often associated with hemodynamic instability and abnormal hematologic indices.
In cases of concealed ongoing bleeding, the clinician must have a high index of suspicion based on physical examination of the mother, such as the presence of a large, boggy uterus, the patient has known placental abnormalities, or placental retained products are suspected after examination of the placenta. Possible lacerations of the lower genital tract should be investigated with manual and digital exploration after traumatic and tumultuous vaginal deliveries.
Most frequent cause of PPH is uterine atony. Risk factors for uterine atony include:
overdistention of the uterus
retained placental products
uterine muscle fatigue
use of halogenated anesthetic agents
Second most frequent cause of PPH is lacerations of the lower genital tract that occur spontaneously or as a result of traumatic labor.
Other less common causes of PPH include disseminated intravascular coagulation (DIC) resulting from placental abnormalities, the HELLP syndrome and the amniotic fluid embolism syndrome (AFES).
Excessive bleeding from the uterus and lower genital tract is directly related to the increase in blood flow to the uterus and placenta.
Complications from postpartum hemorrhage
DIC and dilutional coagulopathy from massive fluid resuscitation and/or massive transfusion requirements of >10 units of PRBC
renal (acute tubular necrosis)
acute respiratory distress syndrome
multisystem organ failure
pituitary avascular necrosis (Sheehan's syndrome)
The prognosis of postpartum hemorrhage will depend on many factors related to diagnosis and treatment. Worse prognoses are seen in those cases of delayed diagnosis and treatment. The cause of bleeding and the duration and extent of bleeding will influence the development of potential maternal complications.
Women with a prior history of PPH have a 10% risk of recurrence with a subsequent pregnancy.
Leading cause of postpartum death worldwide, causing 24% of maternal deaths or an estimated 127,000 maternal deaths annually
In developing countries, PPH may cause up to 60% of all maternal deaths.
Uterine atony occurs in 5% of deliveries.
Special considerations for nursing and allied health professionals.
What's the evidence?
"ACOG Practice Bulletin. Clinical management guidelines for obstetrician-gynecologists. Number 76, October 2006: postpartum hemorrhage". Obstet Gynecol. vol. 108. 2006. pp. 1039-47.(The ACOG (American College of Obstetricians and Gynecologists) Practice Bulletins provide clinicians with current information on diagnostic techniques and clinical management guidelines for a wide variety of clinical scenarios. These guidelines address the etiology, evaluation, and management of postpartum hemorrhage.)
Quinones, JN, User, JB, Gogle, J. "Clinical evaluation during postpartum hemorrhage". Clin Obstet Gynecol. vol. 53. 2010. pp. 157-64.(This review describes an etiology-based approach to the clinical evaluation of postpartum hemorrhage and guidelines that help expedite rapid diagnosis and management of obstetrical hemorrhage.)
Berg, CJ, Callaghan, WM, Syverson, C. "Pregnancy-related mortality in the United States, 1998--2005". Obstet Gynecol. vol. 116. 2010. pp. 1302-9.(The objective of this epidemiologic study was to evaluate the trends of risk factors and causes for maternal mortality in the United States and to identify patients at high risk for death. Although the number of deaths has decreased over time, postpartum hemorrhage remains a significant contributing cause of maternal death.)
Rossi, AC, Lee, RH, Chmait, RH. "Emergency postpartum hysterectomy for uncontrolled postpartum bleeding: a systematic review". Obstet Gynecol. vol. 115. 2010. pp. 637-44.(The objective of this review was to describe factors leading to the need for a postpartum hysterectomy and outcomes after emergency hysterectomy. 981 cases of emergency postpartum hysterectomies were reviewed using multiple databases. Women at highest risk for emergency hysterectomy are those who are multiparous, had a prior cesarean section in either a previous pregnancy or with the present pregnancy, or had abnormal placentation.)
Copyright © 2017, 2013 Decision Support in Medicine, LLC. All rights reserved.
No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The Licensed Content is the property of and copyrighted by DSM.
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- Ultrasonography May Detect Thyroid Cancer Growth Arrest, Negating Need for Treatment
- Do Additional Chromosomal Abnormalities Noted at CML Diagnosis Affect Response and Survival?
- Does Education Level Predict PSA Screening and Prostate Cancer Survival?
- Pembrolizumab May Benefit Selected Patients With Incurable Metastatic Breast Cancer
- Unrelated HSCT, UCBT May Yield Similar Survival Outcomes in Acute Leukemia
- Adjuvant Gefitinib Improves Disease-free Survival Among Patients With NSCLC
- Phase 1 Study of Binimetinib Plus Pexidartinib for GIST
- Phase 2 Study of Nivolumab vs Nivolumab Plus Ipilimumab for GIST
- Pesticides and Cancer
- Goserelin Mitigates Risk of Ovarian Failure, Improves Breast Cancer Survival Rate