Low-Dose Aspirin, NSAIDs May Lower Colorectal Cancer Risk

Share this content:
Regularly taking low-dose aspirin or other nonsteroidal anti-inflammatory drugs may lower long-term risk of colorectal cancer.
Regularly taking low-dose aspirin or other nonsteroidal anti-inflammatory drugs may lower long-term risk of colorectal cancer.

Regularly taking low-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) may lower long-term risk of colorectal cancer (CRC), new research suggests. The study was published in the Annals of Internal Medicine.

John Baron, M.D., a professor of medicine at the University of North Carolina School of Medicine in Chapel Hill, and colleagues reviewed data from several Danish cancer databases to gather the health histories of 10,280 CRC patients diagnosed between 1994 and 2011.

Patients were between the ages of 30 and 85. Medical records were evaluated for aspirin and non-aspirin NSAID consumption patterns.

A comparison of cancer patients with 102,800 cancer-free individuals revealed that regular, long-term use of low-dose aspirin and NSAIDs seemed to confer long-term protection against CRC.

The biggest benefit was linked to agents with high cyclooxygenase-2 selectivity. Taking low-dose (75 to 150 mg) aspirin for five years or more was associated with a 27 percent risk reduction in both men and women. And taking NSAIDs such as ibuprofen for that long was linked to a 30 to 45 percent drop in CRC risk.

RELATED: Post-Diagnosis Aspirin Use Not Linked with Breast Cancer-Specific Mortality

Baron emphasized that the drugs were taken continuously for years before any cancer-preventive benefits were realized. "For aspirin, you would have to take it fairly consistently, meaning at least every other day, for at least five to 10 years for the protective effect to even begin to appear," he told HealthDay.

Reference

  1. Friis S, Riis AH, Erichsen R, et al. Low-Dose Aspirin or Nonsteroidal Anti-inflammatory Drug Use and Colorectal Cancer Risk: A Population-Based, Case–Control Study. Annals of Internal Medicine. 2015. [epub ahead of print]. doi:10.7326/M15-0039.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters