Continuing Cetuximab, Chemo After Progression of mCRC May Be Effective

Share this content:
Continuing cetuximab in combination with chemotherapy after first progression may be efficacious in metastatic colorectal cancer.
Continuing cetuximab in combination with chemotherapy after first progression may be efficacious in metastatic colorectal cancer.

Continuing cetuximab in combination with chemotherapy after first progression may be efficacious in selected patients with metastatic colorectal cancer (mCRC), a study published in the journal Annals of Oncology has shown.1

Cetuximab plus chemotherapy is a first-line treatment modality in patients with metastatic KRAS and NRAS wild type CRC; however, there are currently no data on the effect of continuing anti-epidermal growth factor receptor (EGFR) therapy beyond progression.

For the multicenter, open-label, phase 2 trial, researchers in Italy sought to evaluate the efficacy of cetuximab plus 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) as second-line treatment for patients with KRAS exon 2 wild type mCRC who were treated with first-line 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) plus cetuximab.

Researchers enrolled 153 patients and randomly assigned 75 to receive FOLFOX plus cetuximab and 79 to FOLFOX alone.

Results showed that median progression-free survival was 6.4 months (95% CI, 4.7 - 8.0) with cetuximab compared with 4.5 months (95% CI, 3.3 - 5.7) with FOLFOX alone (HR, 0.81; 95% CI, 0.58 - 1.12; P = .19).

Researchers found that progression-free survival was longer in the FOLFOX plus cetuximab arm among patients with KRAS, NRAS, BRAF, and PIK3CA wild type tumors. Median progression-free survival was 6.9 months (95% CI, 5.5 - 8.2) with FOLFOX plus cetuximab vs 5.3 months (95% CI, 3.7 - 6.9) with FOLFOX (HR, 0.56; 95% CI, 0.33 - 0.94; P = .025). Researchers also observed a trend in prolonged overall survival with immunotherapy (HR, 0.57; 95% CI, 0.32 - 1.02; P = .056).

RELATED: Selective Internal Radiation Therapy Plus FOLFOX Improves Control of Liver Tumors in Colorectal Cancer

The findings suggest that continuing cetuximab and chemotherapy in molecularly selected patients following first progression should be confirmed in phase 3 studies.

Reference

  1. Ciardiello F, Normanno N, Martinelli E, et al. Cetuximab continuation after first progression in metastatic colorectal cancer (CAPRI-GOIM): a randomized phase 2 trial of FOLFOX plus cetuximab versus FOLFOX [published online ahead of print March 21, 2016]. Ann Oncol. doi: 10.1093/annonc/mdw136.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters