FIT-Based Screening Impacts Proximal, Distal Colorectal Cancer Rates

Share this content:
Fecal immunochemical test-based screening programs impact both proximal and distal colorectal cancer rates.
Fecal immunochemical test-based screening programs impact both proximal and distal colorectal cancer rates.

Fecal immunochemical test (FIT)-based screening programs impact both proximal and distal colorectal cancer (CRC) rates, but underlying preexisting epidemiological trends lead to a rapidly increasing percentage of proximal CRC, according to a study published online ahead of print in the journal Cancer.

FIT-based CRC screening programs reduce overall CRC surgery rates, however, data by subset were lacking. The researchers in this study assessed the impact of FIT –based screening on proximal and distal CRC surgical resection rates.

There were three study populations in the trial, all in the Veneto region in Italy. Staggered introduction of FIT-based screening programs were used: early (2002 to 2004), intermediate (2005 to 2007), and late (2008 to 2009). Joinpoint regression analysis and segmented Poisson regression models were used to investigate time series of proximal and distal CRC surgery in the three populations between 2001 and 2012.

Researchers found similar screening impact across the three populations. Rates of distal CRC surgical resection were stable before screening, increased at the time of screening implementation (rate ratio [RR], 1.25; 95% CI, 1.14, 1.37), and declined by 10% annually (RR, 0.90; 95% CI, 0.88, 0.92).

RELATED: For First-line Treatment of Colorectal Cancer, Nintedanib Plus mFOLFOX6 Appears Efficacious

Rates of proximal CRC surgical resection increased 4% annually before screening (RR, 1.04; 95% CI, 1.03, 1.05) up until a peak was reached.

After that peak at the time of screening initiation, the trend was reversed and the percentage of proximal CRC surgery rose from 28% in 2001 to 41% in 2012.

Reference

  1. Fedeli U, Zorzi M, Urso EDL, et al. Impact of fecal immunochemical test-based screening programs on proximal and distal colorectal cancer surgery rates: A natural multiple-baseline experiment. Cancer. 2015. [epub ahead of print]. doi: 10.1002/cncr.29623.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters