In Gastric Adenocarcinoma, GLUT-1, GLUT-14 Are Independent Prognostic Factors

Share this content:
Glucose transporter 1 (GLUT-1) and GLUT-14 are of high prognostic value in gastric adenocarcinoma.
Glucose transporter 1 (GLUT-1) and GLUT-14 are of high prognostic value in gastric adenocarcinoma.

Glucose transporter 1 (GLUT-1) and GLUT-14 are of high prognostic value in gastric adenocarcinoma, a recent study published online ahead of print in the journal Annals of Surgical Oncology has shown.

For the study, researchers analyzed tumor sections that were removed during gastrectomy in 124 patients with gastric adenocarcinoma. Patients underwent surgery between 1996 and 2007. Researchers were looking for associations between GLUT-1, GLUT-14, and HIF1-alpha antibodies and patient survival.

Results showed that median survival in patients with GLUT-1 was 14 months (95% CI: 9.2, 18.8) and 55 months (95% CI: 25.8, 84.2; P=0.01) in patients that were GLUT-1-negative.

Researchers also found that GLUT-14-positive patients had a worse prognosis compared with those that were GLUT-14-negative (P=0.004).

RELATED: Weekly Oraxol for Second-Line Treatment of Metastatic, Recurrent Gastric Cancer

When researchers adjusted for confounding factors in multivariate analysis, GLUT-1 and GLUT-14 continued to be independent factors for prognosis.

The findings suggest that further prospective studies are warranted to confirm these results in order to better identify patients with inferior prognosis.

Reference

  1. Berlth F, Monig S, Pinther B, et al. Both GLUT-1 and GLUT-14 are independent prognostic factors in gastric adenocarcinoma. Ann Surg Oncol. 2015. [epub ahead of print].

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters