Hypofractionated Proton Therapy Demonstrates Local Control

Share this content:
In patients with hepatocellular carcinoma, high-dose hypofractionated proton therapy may demonstrate high local control rates.
In patients with hepatocellular carcinoma, high-dose hypofractionated proton therapy may demonstrate high local control rates.

In patients with hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), high-dose hypofractionated proton therapy may demonstrate high local control rates, according to a recent study published online ahead of print in the Journal of Clinical Oncology.1

Researchers led by Theodore Hong, MD, of the Massachusetts General Hospital in Boston, conducted a single-arm, phase 2, multi-institutional study of 83 patients with biopsy-confirmed HCC or ICC that was determined to be unresectable.  They received 15 fractions of proton therapy to a maximum total dose of 67.5 Gy equivalent.

Observed patients had a Child-Turcotte-Pugh (CTP) score of A or B, an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2, no extrahepatic disease, and no prior radiation. They calculated for patients who were able to demonstrate at least 80% local control as defined by the Response Evaluation Criteria in Solid Tumors (RECIST) 1.0 criteria.

They found that CTP score was A for 79.5% of patients and B for 15.7%, while 4.8% of patients had no cirrhosis. Prior treatment was given to 31.8% of patients with HCC and 61.5% of those with ICC. Multiple tumors were present in 27.3% of patients with HCC and 12.8% of those with ICC.

RELATED: For Hepatocellular Carcinoma, Axitinib May Improve Survival, Time to Progression

With a median dose delivered at 58.0 Gy and a median-follow-up among survivors at 19.5 months, local control at 2 years was 94.8% for patients with HCC and 94.1% for those with ICC. Overall survival rate was found to be 63.2% for HCC and 46.5% for ICC.

Reference

  1. Hong TS, Wo JY, Yeap BY, et al. Multi-institutional phase II study of high-dose hypofractionated proton beam therapy in patients with localized, unresectable hepatocellular carcinoma and intrahepatic cholangiocarcinoma [published online ahead of print December 14, 2015]. J Clin Oncol. doi: 10.1200/JCO.2015.64.2710.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters