Hepatic Resection Provides Long-term Cure for About 10% of Patients With ICC

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Statistical cure from intrahepatic cholangiocarcinoma by hepatic resection was approximately 10% and varied by several tumor-specific factors.
Statistical cure from intrahepatic cholangiocarcinoma by hepatic resection was approximately 10% and varied by several tumor-specific factors.

Statistical cure from intrahepatic cholangiocarcinoma (ICC) by hepatic resection was approximately 10% and varied by several tumor-specific factors, according to an online article published ahead of print in the journal Cancer.

A total of 584 patients who underwent surgery with curative intent for ICC between 1990 and 2013 at one of 12 participating institutions were identified. A nonmixture cure model was adopted to compare mortality after hepatic resection with the mortality expected for the general population matched by sex and age.

Findings showed that median 1-year, 3-year, and 5-year disease-free survival was 10 months, 44%, 18%, and 11%, respectively.

The overall survival was 27 months, 75%, 37%, and 22%, respectively. The mortality of patients undergoing surgery for ICC was higher than that of the general population until year 10.

RELATED: Intra-Arterial Therapy Promising for Intrahepatic Chloangiocarcinoma

Cure probabilities, as measured by multivariate analyses, demonstrated that probabilities ranged from 25.8% (time to cure, 9.8 years) in patients with a single, well-differentiated ICC measuring ≤5 cm that was without vascular/periductal invasion and lymph node metastases versus <0.1% (time to cure, 12.6 years) among patients with six risk factors. Researchers developed a model with which to calculate cure fraction and time to cure was developed.

Reference

  1. Spolverato G, Vitale A, Cucchetti A, et al. Can hepatic resection provide a long-term cure for patients with intrahepatic cholangiocarcinoma? Cancer. 2015. [epub ahead of print]. doi: 10.1002/cncr.29619.

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