General Oncology

Depression as a Side Effect: Exploring a Link Between Certain Cancer Treatments and Mental Health

Depression as a Side Effect: Exploring a Link Between Certain Cancer Treatments and Mental Health

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Researchers are promoting physician and patient awareness about the potential tie between depression and certain therapies.

Psychotherapy and Cancer

Psychotherapy and Cancer

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Some data suggest that psychotherapy may benefit patients with cancer, but higher-quality research is needed.

Is Paraneoplastic Granuloma Annulare Linked to Solid Organ Malignancies?

Is Paraneoplastic Granuloma Annulare Linked to Solid Organ Malignancies?

Recurrence of GA following cancer treatment should signal the possibility of cancer recurrence.

TNFi Not Linked to Increased Risk for Cancer Recurrence in Rheumatoid Arthritis

TNFi Not Linked to Increased Risk for Cancer Recurrence in Rheumatoid Arthritis

TNFi treatment is not associated with increased risk for cancer recurrence in patients with rheumatoid arthritis

Study Reveals Scope of Genomic Variation Within Cancer Cell Lines

Study Reveals Scope of Genomic Variation Within Cancer Cell Lines

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Tumor cell lines derived from single cells and curated at different reference labs have quietly evolved in vitro, accumulating distinct genomic aberrations.

Polypharmacy and Cancer

Polypharmacy and Cancer

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The effect of polypharmacy and noncancer mortality on patient survival and other outcomes in cancer varies by study.

Cognitive Functioning Affects the Ability of Patients With Advanced Cancer to Give Informed Consent

Cognitive Functioning Affects the Ability of Patients With Advanced Cancer to Give Informed Consent

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Approximately half of patients with advanced cancer who are enrolled in phase 1 clinical trials do not know the ultimate goal of the study.

Financial Toxicity and Cancer

Financial Toxicity and Cancer

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Though it is clear that cancer is associated with an extreme financial burden, the extent of the burden varies widely.

Dietary Nitrates/Nitrites and Cancer

Dietary Nitrates/Nitrites and Cancer

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There is concern that added nitrates and nitrites are associated with an increased risk of cancer, but epidemiologic data have been inconclusive thus far.

Do Men Benefit More From Immune Checkpoint Inhibition?

Do Men Benefit More From Immune Checkpoint Inhibition?

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A meta-analysis of 20 randomized clinical trials found that men may infer a greater benefit from immune checkpoint inhibition.

Persistent Cancer Screening Gaps Revealed in New CDC Report

Persistent Cancer Screening Gaps Revealed in New CDC Report

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From 2000 to 2015 screening for breast, cervical, and prostate cancers decreased significantly, whereas screening for colorectal cancer increased significantly.

Population-Level Reductions in Alcohol, Tobacco Use May Reduce Overall Cancer Mortality

Population-Level Reductions in Alcohol, Tobacco Use May Reduce Overall Cancer Mortality

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There has been little historical evidence to show whether modifying per capita use of alcohol and/or tobacco could affect the cancer mortality rate.

Cancer Mortality Rates Differ Across Racial and Ethnic Subgroups

Cancer Mortality Rates Differ Across Racial and Ethnic Subgroups

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The subtle differences within subsets of populations could tell researchers more about how some cancers affect distinct racial or ethnic populations across a heterogeneous group of minorities.

Exercise and Cancer

Exercise and Cancer

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The mechanisms that drive this benefit are not well-understood, and it is believed that the benefit is not just a result of reducing risk factors such as body weight.

Drugs Approved Under the Breakthrough Therapy Pathway Lack Basic Features of High-Quality Trials

Drugs Approved Under the Breakthrough Therapy Pathway Lack Basic Features of High-Quality Trials

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Close postmarketing monitoring will be especially crucial for drugs approved with a breakthrough therapy designation, as many of them were given a pass on the basis of a single pivotal trial.

Triclosan and Cancer Risk: Is There a Link?

Triclosan and Cancer Risk: Is There a Link?

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Some studies suggest triclosan could have oncogenic properties, but more research is needed to confirm a causal link.

CRISPR Method of Gene Editing Creates Massive Genetic Reshuffling

CRISPR Method of Gene Editing Creates Massive Genetic Reshuffling

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Drug developers relying on CRISPR-Cas9 platforms for the creation of gene therapies saw their shares slide when it was revealed that the technique may inadvertently cause disruptions of larger chunks of DNA than previously thought.

FDA-Approved Breast Cancer Drug Treatments

Treatment chart with usual dosage, strength, and formulation of FDA approved medications for breast cancer.

FDA-Approved Colorectal Cancer Drug Treatments

Colorectal cancer treatment regimen chart.

FDA-Approved Non-Small Cell Lung Cancer (NSCLC) Drug Treatments

Non-small cell lung cancer (NSCLC) treatment regimen chart.

FDA-Approved Prostate Cancer Drug Treatments

Approved prostate cancer drug treatments including formulations and usual dosing.

Massage and Cancer

Massage and Cancer

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An overview of the research regarding the use of massage to improve cancer- or treatment-related symptoms and overall quality of life for patients with cancer.

Reprogramming T Cells Without Using Viral Vectors

Reprogramming T Cells Without Using Viral Vectors

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According to recent research, scientists may not need to rely on the use of viral vectors to edit the genes of primary immune cells when creating cell and gene therapies.

Is Genomic Medicine Failing Minority Patients?

Is Genomic Medicine Failing Minority Patients?

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Racial minorities are poorly represented in genomic research databases, raising important questions about whether or not all patients will benefit equally from advances in precision oncology.

Progress Report in Cancer Control: How Are We Doing?

Progress Report in Cancer Control: How Are We Doing?

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An analysis of population data on cancer incidence, survival, and mortality revealed that early interventions and improvements to treatments contributed to a 26% decline in cancer deaths from 1991 to 2015.

Sildenafil and Cancer: The Potential Positives

Sildenafil and Cancer: The Potential Positives

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Examining the costs and benefits of repurposing sildenafil as a cancer medication.

FDA's Accelerated Approval Pathway Needs Active Management

FDA's Accelerated Approval Pathway Needs Active Management

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Results from postmarketing trials for drugs approved through FDA's accelerated approval pathway need to be produced in a more timely fashion to reveal the true benefit — or lack thereof — of the drugs approved through these expedited channels.

Mobile Phones and Cancer

Mobile Phones and Cancer

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Multiple studies have examined the possible association between cell phone usage and increased cancer risk, but study designs, potential biases, and interpretations of statistical outcomes leave conclusions uncertain.

Q&A With Frank Luh, MD, MS, MHA and Yun Yen, MD, PhD, FACP: Looking to Broaden CMS Coverage for NGS Tests

Q&A With Frank Luh, MD, MS, MHA and Yun Yen, MD, PhD, FACP: Looking to Broaden CMS Coverage for NGS Tests

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Restricting use to FDA-approved NGS tests is not an absolute rule that must last forever. But it's a good start, say two physicians.

Young Adult, Adolescent Survivors of Cancer May Have Increased Long-Term Risk for Endocrine Disease

Young Adult, Adolescent Survivors of Cancer May Have Increased Long-Term Risk for Endocrine Disease

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There is a paucity of data regarding the long-term endocrine effects of cancer in adolescent and young adult survivors.

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