Laproscopically Assisted Distal Gastrectomy Safe for Stage 1 Gastric Cancer

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Laproscopically assisted distal gastrectomy is safe for patients with clinical stage 1 gastric cancer.
Laproscopically assisted distal gastrectomy is safe for patients with clinical stage 1 gastric cancer.

SAN FRANCISCO—Laproscopically assisted distal gastrectomy (LADG) is safe and associated with lower incidence of wound complications compared with standard open distal gastrectomy (ODG) for patients with clinical stage 1 gastric cancer, a study (Abstract 4) presented this week at the 2015 Gastrointestinal Cancers Symposium has shown.

Although LADG is widely used for patients with gastric cancer in Eastern countries, large prospective trials have not been conducted to study its use. For this multicenter, controlled phase 3 study (KLASS-01), researchers enrolled 1,416 patients with clinical stage 1 gastric cancer in Korea and randomly assigned them to receive either LADG or ODG.

Results showed that among the 1,256 evaluable patients, the overall complication rate was 13.0% and 19.9% in the LADG group and ODG group, respectively (P=0.001).

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Specifically, the wound complication rate was 3.1% in the LADG group and 7.7% in the ODG group (P<0.001), and the major intra-abdominal complication rate was 7.6% in the LADG group versus 10.3% in the ODG group (P=0.095). The mortality rates were similar between both treatment arms.

The findings suggest that LADG is safe for patients with clinical stage 1 gastric cancer and causes fewer wound complications than ODG.

Reference

  1. Lee H-J, Kim H-H, Han S-U, et al.  Morbidity and mortality after laparoscopy-assisted and open distal gastrectomy for stage I gastric cancer: Results from a multicenter randomized controlled trial (KLASS-01). J Clin Oncol. 2015;33:(suppl 3; abstr 4). 

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