Advanced Pancreatic Cancer: 3 New Agents Improved Outcomes Between 1978-2015

Share this content:
Phase 2 trials of investigational agents for pancreatic cancer treatment do not usually progress to phase 3.
Phase 2 trials of investigational agents for pancreatic cancer treatment do not usually progress to phase 3.

Phase 2 trials of investigational agents for pancreatic cancer treatment do not usually progress to phase 3, according to a study being presented at the 2017 Gastrointestinal Cancers Symposium.1

Treatment outcomes for patients with locally-advanced or metastatic pancreatic cancer are minimally improved since the 1970s. This study was intended to elucidate reasons for this lack of improvement by reviewing results from phase 2 and 3 trials conducted between 1978 and 2015.

One hundred and forty-nine phase 2 trials of 7499 patients with pancreatic cancer were identified, of which the pooled objective response rate was 13.8%. Authors of 56% of the phase 2 trials recommended the investigational agents progress to phase 3, but only 11% did so.

Less than 10% of novel investigational agents proceeded to phase 3 study. Of all reviewed phase 2 studies investigating a novel agent, “only 1 trial was enriched for the biomarker.”

Three agents in phase 3 trials improved clinical outcomes.

RELATED: PEGPH20 May Improve PFS in Pancreatic Cancer

The authors concluded that phase 2 results do not predict progression to phase 3 study or successful results thereof. These conclusions may be explained by factors including “overly optimistic interpretations” of study results, ineffective investigational agents, and heterogeneity among patients.

Reference

  1. Tang M, Chen J, Goldstein D, et al. Correlation of phase 2 trials (Ph2t) results with outcomes of Phase 3 trials (Ph3t) of investigational agents (IA) in locally advanced and metastatic pancreas cancer (LAMPC). J Clin Oncol. 2017;35(suppl):4S. Abstract 227.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs