Weekly Paclitaxel Carboplatin Induction is 'Effective and Well-Tolerated' in Platinum-Resistant Ovarian Cancer

(ChemotherapyAdvisor) – Dose-dense weekly paclitaxel/carboplatin can safely substitute for paclitaxel/cisplatin to reduce induction therapy–associated toxicity among patients diagnosed with progressive platinum-resistant epithelial ovarian cancer (EOC), report authors of a long-term analysis published in the European Journal of Cancer.

“Six cycles weekly paclitaxel/carboplatin followed by six 3-weekly cycles is well-tolerated and highly active in platinum-resistant and platinum-sensitive patients,” reported M.E.L. van der Burg and colleagues at Erasmus MC Rotterdam in Rotterdam, the Netherlands and the University Hospital Leuven, in Belgium.

After 3-weekly paclitaxel/carboplatin, patients with EOC were treated with six cycles weekly paclitaxel (90 mg/m2) and carboplatin AUC (area under the curve) 4 mg/mL/min, followed by six cycles 3-weekly paclitaxel/carboplatin, the authors reported.

“Median progression free survival (PFS) after last platinum was 9 months (range, 0-81 months) in 108 patients; 43 were platinum-resistant, of whom 13 started weekly paclitaxel/carboplatin less than 6 months after progression,” the authors reported. “During 533 weekly cycles, grade 3/4 toxicity included: thrombocytopenia 8%, neutropenia 30%, febrile neutropenia 0.5%. Nonhematologic toxicity was low. Treatment was delayed in 16% and dose reduced in 2% of cycles.”

Median PFS was 8  months (range, 1-21 months) and 13 months (range, 1-46 months) for platinum-resistant and platinum-sensitive patients, respectively. Median overall survival (OS) was 15 (range, 1-69) and 26 (range, 4-93) months, respectively.

“The 13 platinum-resistant patients with a platinum-therapy free interval less than 6 months had a significantly shorter PFS (4 vs. 10 months; P=0.035) and OS (9 vs. 15 months, P=0.002),” the authors noted. “The platinum therapy-free interval seemed to be a good criterion to select poor-risk, platinum-resistant patients.”


Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Breast Cancer Awareness Month Poll

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs