Adding Chemotherapy to Radiotherapy Improves Nasopharyngeal Carcinoma Survival

Share this content:
Adding concomitant chemotherapy to radiotherapy significantly improves survival in advanced nasopharyngeal carcinoma.
Adding concomitant chemotherapy to radiotherapy significantly improves survival in advanced nasopharyngeal carcinoma.

Adding concomitant chemotherapy to radiotherapy significantly improves survival in patients with advanced nasopharyngeal carcinoma, according to a recent study published online ahead of print in The Lancet Oncology.

Pierre Blanchard, MD, of Paris-Saclay University in France, and fellow researchers conducted a meta-analysis of 4,806 patients from 19 trials that measured radiotherapy with or without chemotherapy in patients with non-metastatic nasopharyngeal carcinoma.

The researchers found that addition of chemotherapy to radiotherapy significantly improved overall survival in these patients.

The benefit was consistent for all endpoints – progression-free survival, locoregional control, distant control and cancer mortality.

RELATED: Advanced Nasopharyngeal Carcinoma Patients Have Similar Outcomes with Neoadjuvant Chemo

Interaction between the benefit and timing of chemotherapy showed significant favorability for  concomitant plus adjuvant chemotherapy as well as concomitant without adjuvant chemotherapy, but not either adjuvant or induction chemotherapy alone.

“To our knowledge, this is the first analysis that examines the effect of concomitant chemotherapy with and without adjuvant chemotherapy as distinct groups,” the authors concluded. “Further studies on the specific benefits of adjuvant chemotherapy after concomitant chemoradiotherapy are needed.”

Reference

  1. Blanchard, Pierre, MD, et al. "Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update on the MAC-NPC meta-analysis." The Lancet Oncology. DOI: http://dx.doi.org/10.1016/S1470-2045(15)70126-9. [epub ahead of print]. May 6, 2015.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters