In Locoregionally Advanced Oral Cavity Cancer, Preop Induction Chemo May Not Improve Outcomes

Share this content:
Induction chemotherapy administered before surgery with curative intent did not improve outcomes in locoregionally advanced oral cavity cancer.
Induction chemotherapy administered before surgery with curative intent did not improve outcomes in locoregionally advanced oral cavity cancer.

Induction chemotherapy when administered before surgery with curative intent did not improve outcomes in patients with locoregionally advanced oral cavity cancer, a new study published online ahead of print in the European Journal of Cancer has shown.1

For the study, researchers sought to perform a meta-analysis of phase 3 studies to evaluate the effectiveness and safety of induction chemotherapy prior to surgery for untreated patients with oral cavity cancer.

Two prospective, randomized, phase 3 trials that compared induction chemotherapy followed by surgery with or without adjuvant radiotherapy versus surgery with or without postoperative radiotherapy. The trials included a total of 451 patients with 226 receiving chemotherapy and 225 not receiving chemotherapy. Most patients had stage 3/4 disease.

Results showed that induction chemotherapy was not associated with a significant improvement in loco-regional recurrence, disease-free survival, or overall survival.

RELATED: New Standard of Care for Early Oral Cancer

However, a subgroup analysis demonstrated a statistically significant improvement in overall survival with induction chemotherapy in patients with cN2 disease.

The findings suggest that clinically assessed patients with locoregionally advanced N2 oral cavity cancer may benefit from induction chemotherapy.

Reference

  1. Marta GN, Riera R, Bossi P, et al; Induction chemotherapy prior to surgery with or without postoperative radiotherapy for oral cavity cancer patients: systematic review and meta-analysis [published online ahead of print August 26, 2015]. E J Cancer. doi: 10.1016/j.ejca.2015.08.007.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters