Azacitadine May Be Safe, Effective for Older Patients with Acute Myeloid Leukemia
the Cancer Therapy Advisor take:
Azacitadine may be an important treatment option for older patients with newly diagnosed acute myeloid leukemia (AML) with >30% blasts, a new study published online in the journal Blood has shown.
For the multicenter, open-label, phase III trial, researchers enrolled 488 patients at least 65 years of age with newly diagnosed AML with >30% bone marrow blasts. Patients were randomly assigned 1:1 to receive azacitadine or a conventional care regimen, which included either standard induction chemotherapy, low-dose cytarabine, or supportive care only.
Results showed that median overall survival was 10.4 months (95% CI: 8.0-12.7) in the azacitadine group compared with 6.5 months (95% CI: 5.0-8.6) in the conventional care group (HR = 0.85; 95% CI: 0.69-1.03; P = 0.1009). Researchers found that the 1-year survival rates were 46.5% and 34.2% with azacitadine and conventional care regimens, respectively.
In regard to safety, adverse events were similar to those observed in previous studies with azacitadine.
Azacitadine may be an important treatment option for older patients with newly diagnosed AML.
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