Non-Hodgkin Lymphoma (NHL) Treatment Regimens: Peripheral T-Cell Lymphoma

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NON-HODGKIN LYMPHOMA TREATMENT REGIMENS:

Peripheral T-Cell Lymphoma

Clinical Trials: The NCCN recommends cancer patient participation in clinical trials as the gold standard for treatment.

Cancer therapy selection, dosing, administration, and the management of related adverse events can be a complex process that should be handled by an experienced healthcare team. Clinicians must choose and verify treatment options based on the individual patient; drug dose modifications and supportive care interventions should be administered accordingly. The non-hodgkin lymphoma (peripheral t-cell lymphoma) cancer treatment regimens below may include both U.S. Food and Drug Administration-approved and unapproved indications/regimens. These non-hodgkin lymphoma (peripheral t-cell lymphoma) cancer treatment regimens are provided only to supplement the latest treatment strategies.

These Cancer Treatment Guidelines are a work in progress that may be refined as often as new significant data becomes available. The NCCN Guidelines® are a consensus statement of its authors regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult any NCCN Guidelines® is expected to use independent medical judgment in the context of individual clinical circumstances to determine any patient's care or treatment. The National Comprehensive Cancer Network makes no warranties of any kind whatsoever regarding their content, use, or application and disclaims any responsibility for their application or use in any way.

(Revised 9/2016)

© 2016 by Haymarket Media, Inc.

Systemic Therapy for Peripheral T-Cell Lymphomas1

Note: All recommendations are Category 2A unless otherwise indicated.

First-Line Therapy ALCL, ALK+ Histology

REGIMEN

DOSING

CHOP-212-5a

Day 1: Cyclophosphamide 750mg/m2 IV + doxorubicin 50mg/m2 IV + vincristine 2mg IV

Days 1–5: Prednisone 100mg orally.

Repeat every 3 weeks for 6 cycles.

CHOEP3-5a

Day 1: Cyclophosphamide 750mg/m2 IV + doxorubicin 50mg/m2 IV + vincristine 2mg IV

Days 1–3: Etoposide 100mg/m2 IV

Days 1–5: Prednisone 100mg orally.

Repeat every 3 weeks for 6 cycles.

First-Line Therapy for Other Histologies (ALCL, ALK, PTCL, NOS, AITL, EATL)

Preferred Regimens

CHOEP3-5

Day 1: Cyclophosphamide 750mg/m2 IV + doxorubicin 50mg/m2 IV + vincristine 2mg IV

Days 1–3: Etoposide 100mg/m2 IV

Days 1–5: Prednisone 100mg orally.

Repeat every 3 weeks for 6 cycles.

CHOP-142-5

Day 1: Cyclophosphamide 750mg/m2 IV + doxorubicin 50mg/m2 IV + vincristine 2mg IV

Days 1–5: Prednisone 100mg orally.

Repeat every 2 weeks for 6 cycles.

CHOP-212-5

Day 1: Cyclophosphamide 750mg/m2 IV + doxorubicin 50mg/m2 IV + vincristine 2mg IV

Days 1–5: Prednisone 100mg orally.

Repeat every 3 weeks for 6 cycles.

Dose-adjusted EPOCH6-8

Days 1–4, via continuous infusion for 96 hours: Etoposide 50mg/m2 IV + vincristine 0.4mg/m2 IV + doxorubicin 10mg/m2 IV

Days 1–6: Prednisone 60mg orally

Day 6: Cyclophosphamide 750mg/m2 IV.

Repeat every 21 days until complete response.

Alternative Regimens

CHOP followed by IVE alternating with intermediate-dose methotrexate (Newcastle Regimen)9b

Day 1: Cyclophosphamide 750mg/m2 IV + doxorubicin 50mg/m2 IV + vincristine 1.4mg/m2 (max dose 2mg) + prednisone 100mg orally daily for 1 cycle.

Repeat every 3 weeks for 6–8 cycles, followed by:

Days 1–3: Ifosfamide 3000mg/m2 IV + etoposide 200mg/m2 IV + epirubicin 50mg/m2 IV + methotrexate 1500mg/m2 IV.

Repeat every 3 weeks for 3 cycles.

HyperCVAD alternating with high-dose methotrexate and cytarabine10,11

Days 1–2: Methotrexate 200mg/m2 IV bolus followed by methotrexate 800mg/m2 IV over 24 hours

Days 1–3: Cyclophosphamide 300mg/m2 IV every 12 hours for 6 doses with mesna 600mg/m2/day

Days 1–4 and Days 11–14: Dexamethasone 40mg orally

Day 3: Cytarabine 3000mg/m2 IV every 12 hours for 4 doses

OR

Day 3: Cytarabine 1000mg/m2 IV for patients >60 years or serum creatinine

>1.5mg/dL and folic acid 50mg orally 24 hours after the end of methotrexate

followed by folic acid 15mg orally every 6 hours for 8 doses

Days 4–5: Doxorubicin 25mg/m2 IV via continuous infusion over 24 hours;

G-CSF 5mcg/kg 24 hours after the end of doxorubicin until granulocyte count

>4500/uL followed by methotrexate and cytarabine (begins immediately after

clinical and hematologic recovery from HyperCVAD course)

Days 4 and 11: Vincristine 2mg/m2 IV (first dose 12 hours after last dose of

cyclophosphamide).

Repeat every 3 weeks for 4 cycles.

First-Line Consolidation

High-dose therapy and stem cell rescue1

• Consider consolidation with high-dose therapy and stem cell rescue

• Patients with low IPI ALCL, ALK+ disease in remission do not need consolidative transplant

Second-line Therapy (With Intention to Proceed to Transplant) & Subsequent Therapy for PTCL-NOS and EATL

Preferred Regimens

Belinostat12

Days 1–5: Belinostat 1,000mg/m2 IV over 30 minutes.

Repeat every 3 weeks until disease progression or unacceptable toxicity.

Brentuximab vedotin for CD30+ PTCL13,14

Day 1: Brentuximab vedotin 1.8mg/kg IV over 30 minutes.

Repeat every 3 weeks until disease progression.

Pralatrexate15

Day 1: Pralatrexate 30mg/m2/week starting for 6 weeks followed by 1 week of rest.

Repeat every 7 weeks until disease progression or unacceptable toxicity.

Romidepsin16,17

Days 1, 8, and 15: Romidepsin 14mg/m2 IV infusion over 4 hours.

Repeat every 28 days for up to 6 cycles.

DHAP18,19

Day 1: Cisplatin 100mg/m2 continuous IV infusion over 24 hours followed by

Day 2: Cytosine arabinoside in 2 pulses each at a 2g/m2 given 12 hours apart

Days 1–4: Dexamethasone 40mg orally or IV.

Repeat every 3–4 weeks for 6–10 cycles.

ESHAP20

Days 1–4: Etoposide 40mg/m2 + cisplatin 25mg/m2 IV via 24-hour continuous infusion

Days 1–5: Methylprednisolone 500mg IV

Day 5: Cytarabine 2g/m2 IV over 2–3 hours.

Repeat every 3–4 weeks for 6–8 cycles.

GDP21-23

Day 1: Cisplatin 75mg/m2 IV over 1 hour

Days 1 and 8: Gemcitabine 100mg/m2 IV over 30 minutes

Days 1–4: Dexamethasone 40mg in divided doses orally.

Repeat every 21 days for 6 cycles.

GemOX24

Day 1: Gemcitabine 1000mg/m2 IV + oxaliplatin 100mg/m2 IV.

Repeat every 15 (with G-CSF) or 21 days for 6 to 8 cycles.

ICE25

Day 1: Ifosfamide 5g/m2 via 24-hour continuous IV infusion

Days 1–3: Etoposide 100mg/m2 IV bolus

Day 2: Carboplatin AUC 5mg·min/mL IV.

Repeat every 2 weeks for 3 cycles.

Alternative Regimens

Bendamustine26

Days 1 and 2: Bendamustine 120mg/m2/day IV.

Repeat every 3 weeks for 6 cycles.

Gemcitabine27,28

Days 1, 8, and 15: Gemcitabine 1200mg/m2 IV.

Repeat every 28 days for 3 cycles.

Lenalidomide29

Days 1–21: Lenalidomide 25mg orally once daily.

Repeat every 28 days until disease progression or unacceptable toxicity.

GVD30c

Day 1: Liposomal doxorubicin 20mg/m2 IV

Days 1 and 8: Gemcitabine 800-1000mg/m2 IV + vinorelbine 25mg/m2 IV.

Repeat every 21 days for 2 to 6 cycles.

Second-line Therapy (With no Intention to Transplant) & Subsequent Therapy for PTCL-NOS and EATL

Preferred Regimens

Belinostat12

Days 1–5: Belinostat 1,000mg/m2 IV over 30 minutes.

Repeat every 3 weeks until disease progression or unacceptable toxicity.

Brentuximab vedotin for CD30+ PTCL13,14

Day 1: Brentuximab vedotin 1.8mg/kg IV over 30 minutes.

Repeat every 3 weeks until disease progression.

Pralatrexate15

Day 1: Pralatrexate 30mg/m2/week starting for 6 weeks followed by 1 week of rest.

Repeat every 7 weeks until disease progression or unacceptable toxicity

Romidepsin16,17

Days 1, 8, and 15: Romidepsin 14mg/m2 IV infusion over 4 hours.

Repeat every 28 days for up to 6 cycles.

Alternative Regimens

Alemtuzumab31

Day 1: Alemtuzumab 3mg IV

Day 3: Alemtuzumab 10mg IV, followed by 30mg IV three times a week.

Repeat every week for a max of 12 weeks.

Bendamustine26

Days 1 and 2: Bendamustine 120mg/m2/day IV.

Repeat every 3 weeks for 6 cycles.

Bortezomib (Category 2B)32d

Days 1, 4, 8, and 11: Bortezomib 1.3mg/m2 IV followed by a 1-week rest period.

Repeat every 21 days for 6 cycles.

Gemcitabine27,28

Days 1, 8, and 15: Gemcitabine 1200mg/m2 IV.

Repeat every 28 days for 3 cycles.

Lenalidomide29

Days 1–21: Lenalidomide 25mg orally once daily.

Repeat every 28 days until disease progression or unacceptable toxicity.

Second-line Therapy (With Intention to Proceed to Transplant) & Subsequent Therapy for AITL

Preferred Regimens

Belinostat12

Days 1–5: Belinostat 1,000mg/m2 IV over 30 minutes.

Repeat every 3 weeks until disease progression or unacceptable toxicity.

Romidepsin16,17

Days 1, 8, and 15: Romidepsin 14mg/m2 IV infusion over 4 hours.

Repeat every 28 days for up to 6 cycles.

DHAP18,19

Day 1: Cisplatin 100mg/m2 continuous IV infusion over 24 hours followed by

Day 2: Cytosine arabinoside in 2 pulses each at a 2g/m2 given 12 hours apart

Days 1–4: Dexamethasone 40mg orally or IV.

Repeat every 3–4 weeks for 6–10 cycles.

ESHAP20

Days 1–4: Etoposide 40mg/m2 + cisplatin 25mg/m2 IV via 24-hour continuous infusion

Days 1–5: Methylprednisolone 500mg IV

Day 5: Cytarabine 2g/m2 IV over 2–3 hours.

Repeat every 3–4 weeks for 6–8 cycles.

GDP21-23

Day 1: Cisplatin 75mg/m2 IV over 1 hour

Days 1 and 8: Gemcitabine 100mg/m2 IV over 30 minutes

Days 1–4: Dexamethasone 40mg in divided doses orally.

Repeat every 21 days for 6 cycles.

GemOX24

Day 1: Gemcitabine 1000mg/m2 IV + oxaliplatin 100mg/m2 IV.

Repeat every 15 (with G-CSF) or 21 days for 6 to 8 cycles.

ICE25

Day 1: Ifosfamide 5g/m2 via 24-hour continuous IV infusion

Days 1–3: Etoposide 100mg/m2 IV bolus

Day 2: Carboplatin AUC 5mg·min/mL IV.

Repeat every 2 weeks for 3 cycles.

Alternative Regimens

Bendamustine26

Days 1 and 2: Bendamustine 120mg/m2/day IV.

Repeat every 3 weeks for 6 cycles.

Gemcitabine27,28

Days 1, 8, and 15: Gemcitabine 1200mg/m2 IV.

Repeat every 28 days for 3 cycles.

Lenalidomide29

Days 1–21: Lenalidomide 25mg orally once daily.

Repeat every 28 days until disease progression or unacceptable toxicity.

Pralatrexate15f

Day 1: Pralatrexate 30mg/m2/week starting for 6 weeks followed by 1 week of rest.

Repeat every 7 weeks until disease progression or unacceptable toxicity.

Second-line Therapy (With no Intention to Transplant) & Subsequent Therapy for AITL

Preferred Regimens

Belinostat12

Days 1–5: Belinostat 1,000mg/m2 IV over 30 minutes.

Repeat every 3 weeks until disease progression or unacceptable toxicity.

Romidepsin16,17

Days 1, 8, and 15: Romidepsin 14mg/m2 IV infusion over 4 hours.

Repeat every 28 days for up to 6 cycles.

Alternative Regimens

Alemtuzumab31

Day 1: Alemtuzumab 3mg IV

Day 3: Alemtuzumab 10mg IV, followed by 30mg IV three times a week.

Repeat every week for a max of 12 weeks.

Bendamustine26

Days 1 and 2: Bendamustine 120mg/m2/day IV.

Repeat every 3 weeks for 6 cycles.

Bortezomib (Category 2B)32d

Days 1, 4, 8, and 11: Bortezomib 1.3mg/m2 IV followed by a 1-week rest period.

Repeat every 21 days for 6 cycles.

Cyclosporine33g

Cyclosporine 3–5mg/kg orally for 6–8 weeks; taper by 50mg every 1–3 weeks.

Responding patients received maintenance dose of 50–100mg with gradual

taper after maximal response was achieved.

Gemcitabine27,28

Days 1, 8, and 15: Gemcitabine 1200mg/m2 IV.

Repeat every 28 days for 3 cycles.

Lenalidomide29

Days 1–21: Lenalidomide 25mg orally once daily.

Repeat every 28 days until disease progression or unacceptable toxicity.

Pralatrexate15f

Day 1: Pralatrexate 30mg/m2/week starting for 6 weeks followed by 1 week of rest.

Repeat every 7 weeks until disease progression or unacceptable toxicity.

Second-line Therapy (With Intention to Proceed to Transplant) & Subsequent Therapy for AITL

Preferred Regimens

Belinostat12

Days 1–5: Belinostat 1,000mg/m2 IV over 30 minutes.

Repeat every 3 weeks until disease progression or unacceptable toxicity.

Brentuximab vedotin34,35

Day 1: Brentuximab vedotin 1.8mg/kg IV over 30 minutes.

Repeat every 3 weeks until disease progression.

Pralatrexate15

Day 1: Pralatrexate 30mg/m2/week starting for 6 weeks followed by 1 week of rest.

Repeat every 7 weeks until disease progression or unacceptable toxicity.

Romidepsin16,17

Days 1, 8, and 15: Romidepsin 14mg/m2 IV infusion over 4 hours.

Repeat every 28 days for up to 6 cycles.

DHAP18,19

Day 1: Cisplatin 100mg/m2 continuous IV infusion over 24 hours followed by

Day 2: Cytosine arabinoside in 2 pulses each at a 2g/m2 given 12 hours apart

Days 1–4: Dexamethasone 40mg orally or IV.

Repeat every 3–4 weeks for 6–10 cycles.

ESHAP20

Days 1–4: Etoposide 40mg/m2 + cisplatin 25mg/m2 IV via 24-hour

continuous infusion

Days 1–5: Methylprednisolone 500mg IV

Day 5: Cytarabine 2g/m2 IV over 2–3 hours.

Repeat every 3–4 weeks for 6–8 cycles.

GDP21-23

Day 1: Cisplatin 75mg/m2 IV over 1 hour

Days 1 and 8: Gemcitabine 100mg/m2 IV over 30 minutes

Days 1–4: Dexamethasone 40mg in divided doses orally.

Repeat every 21 days for 6 cycles.

GemOX24

Day 1: Gemcitabine 1000mg/m2 IV + oxaliplatin 100mg/m2 IV.

Repeat every 15 (with G-CSF) or 21 days for 6 to 8 cycles.

ICE25

Day 1: Ifosfamide 5g/m2 via 24-hour continuous IV infusion

Days 1–3: Etoposide 100mg/m2 IV bolus

Day 2: Carboplatin AUC 5mg·min/mL IV.

Repeat every 2 weeks for 3 cycles.

Alternative Regimens

Bendamustine26

Days 1 and 2: Bendamustine 120mg/m2/day IV.

Repeat every 3 weeks for 6 cycles.

Gemcitabine27,28

Days 1, 8, and 15: Gemcitabine 1200mg/m2 IV.

Repeat every 28 days for 3 cycles.

Second-line Therapy (With no Intention to Transplant) & Subsequent Therapy for ALCL

Preferred Regimens

Belinostat12

Days 1–5: Belinostat 1,000mg/m2 IV over 30 minutes.

Repeat every 3 weeks until disease progression or unacceptable toxicity.

Brentuximab vedotin34,35

Day 1: Brentuximab vedotin 1.8mg/kg IV over 30 minutes.

Repeat every 3 weeks until disease progression.

Pralatrexate15

Day 1: Pralatrexate 30mg/m2/week starting for 6 weeks followed by 1 week of rest.

Repeat every 7 weeks until disease progression or unacceptable toxicity.

Romidepsin16,17

Days 1, 8, and 15: Romidepsin 14mg/m2 IV infusion over 4 hours.

Repeat every 28 days for up to 6 cycles.

Alternative Regimens

Alemtuzumab31

Day 1: Alemtuzumab 3mg IV

Day 3: Alemtuzumab 10mg IV, followed by 30mg IV three times a week.

Repeat every week for a max of 12 weeks.

Bendamustine26

Days 1 and 2: Bendamustine 120mg/m2/day IV.

Repeat every 3 weeks for 6 cycles.

Bortezomib (Category 2B)32d

Days 1, 4, 8, and 11: Bortezomib 1.3mg/m2 followed by a 1-week rest period.

Repeat every 21 days for 6 cycles.

Gemcitabine27,28

Days 1, 8, and 15: Gemcitabine 1200mg/m2 IV.

Repeat every 28 days for 3 cycles.

a While CHOP-21 and CHOEP regimens confer a favorable prognosis in ALCL, ALK +, these regimens have not provided the same c favorable results for other PTCL histologies; clinical trial is therefore preferred for the management of these other histologies.

b CHOP followed by IVE regimen includes HSCT.

c Data suggest there may be excessive pulmonary toxicity with GVD (gemcitabine, vinorelbine, liposomal doxorubicin) regimen when used in combination with unconjugated anti-CD30 monoclonal antibodies for the treatment of Hodgkin lymphoma. A similar regimen, gemcitabine and liposomal doxorubicin, may be used for mature T-cell lymphoma; however, it is recommended to wait 3–4 weeks following e treatment with brentuximab vedotin before initiation.36

d Activity has been demonstrated in small clinical trials and additional larger trials are needed.

e In AITL, pralatrexate has limited activity.

f With close follow-up of renal function.

References

1. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Non-Hodgkin's Lymphomas V3.2016. Available at: http://www.nccn.org. Accessed September 13, 2016.

2. Savage KJ, Chhanabhai M, Gascoyne RD, Connors JM. Characterization of peripheral T-cell lymphomas in a single North American institution by the WHO classification. Ann Oncol. 2004;15:1467–1475.

3. Pfreundschuh M, Trümper L, Kloess M, et al. German high grade non-Hodgkin's Lymphoma Study Group. Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of young patients with good-prognosis (normal LDH) aggressive lymphomas: results of the NHL-B1 trial of the DSHNHL. Blood. 2004;104:626–633.

4. Pfreundschuh M, Trümper L, Kloess M, et al. German high-grade non-Hodgkin's Lymphoma Study Group. Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: results of the NHL-B2 trial of the DSHNHL. Blood. 2004;104:634–641.

5. Schmitz N, Trumper L, Ziepert M, et al. Treatment and prognosis of mature T-cell and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin Lymphoma Study Group. Blood. 2010;116;3418–3425.

6. Dunleavy K, Shovlin M, Pittaluga S, et al. DA-EPOCH Chemotherapy is highly effective in ALK-positive and ALK-negative ALCL: Results of a prospective study of PTCL subtypes in adults [abstract]. Blood. 2011;118:Abstract 1618.

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9. Sieniawski M, Angamuthu N, Boyd K, et al. Evaluation of enteropathy-associated T-cell lymphoma comparing standard therapies with a novel regimen including autologous stem cell transplantation. Blood. 2010;115:3664–3670.

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11. Pozadzides JV, Perini G, Hess M, et al. Prognosis and treatment of patients with peripheral T-cell lymphoma: The M. D. Anderson Cancer Center experience. J Clin Oncol. 2010;28:Abstract 8051.

12. O'Connor OA, Horwitz S, Masszi T, et al. Belinostat in patients with relapsed or refractory peripheral T-cell lymphoma: Results of the pivotal phase II BELIEF (CLN-19) study. J Clin Oncol. 2015;33:2492–2499.

13. Jacobsen ED, Advani RH, Oki Y, et al. A phase 2 study of brentuximab vedotin in patients with relapsed or refractory CD30-positive non-Hodgkin lymphomas: Interim results [abstract]. Blood. 2012;120: Abstract 2746.

14. Horwitz SM, Advani RH, Bartlett NL, et al. Objective responses in relapsed T-cell lymphomas with single agent brentuximab vedotin. Blood. 2014;123:3095–3100.

15. O'Connor OA, Pro B, Pinter-Brown L, et al. Pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma: Results from the pivotal PROPEL study. J Clin Oncol. 2011;29:1182–1189.

16. Coiffier B, Pro B, Prince HM, et al. results from a pivotal, open-label, phase ii study of romidepsin in relapsed or refractory peripheral T-cell lymphoma after prior systemic therapy. J Clin Oncol. 2012;30:631–636.

17. Coiffier B, Pro B, Prince HM, et al. Romidepsin for the treatment of relapsed/refractory peripheral T-cell lymphoma: pivotal study update demonstrates durable responses. J Hematol Oncol. 2014;7:11.

18. Velasquez WS, Cabanillas F, Salvador P, et al. Effective salvage therapy for lymphoma with cisplatin in combination with high-dose Ara-C and dexamethasone (DHAP). Blood. 1988;71:117–122.

19. Mey UJ, Orlopp KS, Flieger D, et al. Dexamethasone, high-dose cytarabine, and cisplatin in combination with rituximab as salvage treatment for patients with relapsed or refractory aggressive non-Hodgkin's lymphoma. Cancer Invest. 2006;24:593–600.

20. Velasquez WS, McLaughlin P, Tucker S, et al. ESHAP—an effective chemotherapy regimen in refractory and relapsing lymphoma: a 4-year follow-up study. J Clin Oncol. 1994;12:1169–1176.

21. Crump M, Baetz T, Couban S, et al. Gemcitabine, dexamethasone, and cisplatin in patients with recurrent or refractory aggressive histology B-cell non-Hodgkin lymphoma: a Phase II study by the National Cancer Institute of Canada Clinical Trials Group (NCIC-CTG). Cancer. 2004;101:1835–1842.

22. Dong M, He XH, Liu P, et al. Gemcitabine-based combination regimen in patients with peripheral T-cell lymphoma. Med Oncol. 2013;30:351.

23. Connors JM, Sehn LH, Villa D, et al. Gemcitabine, dexamethasone, and cisplatin (GDP) as secondary chemotherapy in relapsed/refractory peripheral T-cell lymphoma [abstract]. Blood. 2013;122:Abstract 4345.

24. Lopez A, Gutierrez A, Palacios A, et al. GEMOX-R regimen is a highly effective salvage regimen in patients with refractory/relapsing diffuse large-cell lymphoma: A phase II study. Eur J Haematol. 2008;80:127–132.

25. Zelenetz AD, Hamlin P, Kewalramani T, et al. Ifosfamide, carboplatin, etoposide (ICE)-based second-line chemotherapy for the management of relapsed and refractory aggressive non-Hodgkin's lymphoma. Ann Oncol. 2003;14[suppl 1]:i5–10.

26. Damaj G, Gressin R, Bouabdallah K, et al. Results from a prospective, open-label, phase II trial of bendamustine in refractory or relapsed T-cell lymphomas: the BENTLY trial. J Clin Oncol. 2013;31:104–110.

27. Zinzani PL, Baliva G, Magagnoli M, et al. Gemcitabine treatment in pretreated cutaneous T-cell lymphoma: Experience in 44 patients. J Clin Oncol. 2000;18:2603–2606.

28. Zinzani PL, Magagnoli M, Bendandi M, et al. Therapy with gemcitabine in pretreated peripheral T-cell lymphoma patients. Ann Oncol. 1998;9:1351–1353.

29. Morschhauser F, Fitoussi O, Haioun C, et al. A phase 2, multicentre, single-arm, open-label study to evaluate the safety and efficacy of single-agent lenalidomide (Revlimid) in subjects with relapsed or refractory peripheral T-cell non-Hodgkin lymphoma: the EXPECT trial. Eur J Cancer. 2013;49(13):2869–2876.

30. Qian Z, Song Z, Zhang H, et al. Gemcitabine, navelbine, and doxorubicin as treatment for patients with refractory or relapsed T-cell lymphoma. Biomed Res Int. 2015;2015:606752.

31. Enblad G, Hagberg H, Erlanson M, et al. A pilot study of alemtuzumab (anti-CD52 monoclonal antibody) therapy for patients with relapsed or chemotherapy-refractory peripheral T-cell lymphomas. Blood. 2004;103:2920–2924.

32. Zinzani PL, Musuraca G, Tani M, et al. Phase II trial of proteasome inhibitor bortezomib in patients with relapsed or refractory cutaneous T-cell lymphoma. J Clin Oncol. 2007;25(27):4293–4297.

33. Advani R, Horwitz S, Zelenetz A, Horning SJ. Angioimmunoblastic T cell lymphoma: treatment experience with cyclosporine. Leuk Lymphoma. 2007;48:521–525.

34. Pro B, Advani R, Brice P, et al. Brentuximab vedotin (SGN-35) in patients with relapsed or refractory systemic anaplastic large-cell lymphoma: Results of a phase II study. J Clin Oncol. 2012;30:2190–2196.

35. Advani RH, Brice P, Bartlett NL, et al. Three-year survival results from an ongoing phase 2 study of brentuximab vedotin in patients with relapsed or refractory systemic anaplastic large cell lymphoma. Blood. 2013;122:1809.

36. Blum KA, Jung S-H, Johnson JL, et al. Serious pulmonary toxicity in patients with Hodgkin's lymphoma with SGN-30, gemcitabine, vinorelbine, and liposomal doxorubicin is associated with an FcgRIIIa-158 V/F polymorphism. Ann Oncol. 2010;21:2246–2254.


Hematologic Cancer Drug Monographs

Leukemias, Lymphomas, And Other Hematologic Cancers

ADCETRIS ALKERAN ALKERAN FOR INJECTION
ARRANON ARZERRA BELEODAQ
BENDEKA BEXXAR BICNU
BLEOMYCIN BLINCYTO BOSULIF
BUSULFEX CAMPATH CERUBIDINE
CLADRIBINE CLOLAR CYCLOPHOSPHAMIDE
CYTARABINE CYTOXAN INJECTION DACOGEN
DARZALEX DEPOCYT DOXIL
DOXORUBICIN HCL DOXORUBICIN HCL SOLUTION DTIC-DOME
EMPLICITI ERWINAZE EVOMELA
FARYDAK FLUDARA FOLOTYN
GAZYVA GLEEVEC GLEOSTINE
HYDREA ICLUSIG IDAMYCIN
IDAMYCIN PFS IMBRUVICA INTRON A
INTRON A SOLN ISTODAX JAKAFI
KEYTRUDA KYPROLIS LEUKERAN
MARQIBO MATULANE METHOTREXATE FOR INJECTION
METHOTREXATE INJECTION MITOXANTRONE HCL MUSTARGEN
MYLERAN NINLARO ONCASPAR
ONTAK OPDIVO PAMIDRONATE DISODIUM INJECTION
PENTOSTATIN POMALYST PURINETHOL
PURIXAN REVLIMID RITUXAN
SPRYCEL SYNRIBO TABLOID
TARGRETIN TARGRETIN GEL TASIGNA
THALOMID TREANDA TREXALL
TRISENOX UVADEX VALCHLOR
VELCADE VENCLEXTA VESANOID
VIDAZA VINBLASTINE FOR INJECTION VINBLASTINE INJECTION
VINCASAR PFS VUMON ZEVALIN
ZOLINZA ZOMETA ZYDELIG

Data provided by the Monthly Prescribing Reference (MPR) Hematology/Oncology Edition.

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