Hepatocellular Carcinoma

Prophylactic Effect of Urea-Based Cream on Sorafenib Skin Reactions

Prophylactic Effect of Urea-Based Cream on Sorafenib Skin Reactions

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Onset of sorafenib-associated hand-foot skin reactions can be delayed by urea-based cream plus best supportive care in advanced hepatocellular carcinoma.

Surgical Resection Improves Survival in BCLC Stage C Hepatocellular Carcinoma

Surgical Resection Improves Survival in BCLC Stage C Hepatocellular Carcinoma

Surgical resection provides better survival compared to transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC).

Lenalidomide Shows Promising Activity for Second-Line Hepatocellular Cancer

Lenalidomide Shows Promising Activity for Second-Line Hepatocellular Cancer

Fibroblast growth factor (FGF) is an important growth factor in hepatocellular cancer (HCC).

eNOS Polymorphisms May Influence Prognosis in Hepatocellular Carcinoma Treated with Sorafenib

eNOS Polymorphisms May Influence Prognosis in Hepatocellular Carcinoma Treated with Sorafenib

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Endothelial nitric oxide synthase (eNOS) VNTR and eNOS -786 could determine outcomes in advanced hepatocellular carcinoma treated with sorafenib,

In Advanced Hepatocellular Carcinoma, Baseline AFP May Predict Response to Ramucirumab

In Advanced Hepatocellular Carcinoma, Baseline AFP May Predict Response to Ramucirumab

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Baseline α-fetoprotein (AFP) levels may be a predictive marker for advanced hepatocellular carcinoma receiving ramucirumab.

Addition of Erlotinib to Sorafenib Does Not Improve Survival in Advanced Liver Cancer

Addition of Erlotinib to Sorafenib Does Not Improve Survival in Advanced Liver Cancer

Addition of erlotinib to sorafenib does not improve survival in patients with advanced hepatocellular carcinoma.

A New Approach to Assessing Liver Function in Hepatocellular Carcinoma

A New Approach to Assessing Liver Function in Hepatocellular Carcinoma

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By analyzing data from international databases, researchers develop an alternative to the Child-Pugh system.

Safety, Efficacy of Sorafenib Treatment for Hepatocellular Carcinoma Among Age Groups

Safety, Efficacy of Sorafenib Treatment for Hepatocellular Carcinoma Among Age Groups

Safety and efficacy of sorafenib, the standard of care for advanced hepatocellular carcinoma, in older patients, evaluated.

Linifanib Fails to Meet Overall Survival Endpoint for Advanced Hepatocellular Carcinoma

Linifanib Fails to Meet Overall Survival Endpoint for Advanced Hepatocellular Carcinoma

Linifanib and sorafenib had similar overall survival for the treatment of advanced hepatocellular carcinoma (HCC).

Duration Associated with Survival in Advanced Hepatocellular Carcinoma Treated with Sorafenib

Duration Associated with Survival in Advanced Hepatocellular Carcinoma Treated with Sorafenib

Duration of stability linked with overall survival in advanced hepatocellular carcinoma treated with the tyrosine kinase inhibitor sorafenib.

Vegetables, Not Fruit, Reduce Risk of Hepatocellular Carcinoma

Vegetables, Not Fruit, Reduce Risk of Hepatocellular Carcinoma

Reduction in summary relative risk of hepatocellular carcinoma with increased vegetable, but not fruit, intake.

Everolimus Use in Sorafenib-Refractory Hepatocellular Carcinoma

Everolimus Use in Sorafenib-Refractory Hepatocellular Carcinoma

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Researchers continue to search for a molecular pathway or biomarker to improve treatment options for patients with sorafenib-refractory HCC.

ENMD-2076 Receives Orphan Drug Designation for HCC

ENMD-2076 Receives Orphan Drug Designation for HCC

CASI Pharmaceuticals announced that the FDA has granted Orphan Drug designation to ENMD-2076 for the treatment of hepatocellular carcinoma.

Everolimus Didn't Improve Survival in Advanced HCC

Everolimus Didn't Improve Survival in Advanced HCC

Researchers found no survival difference found between patients receiving everolimus or placebo.

Benefits of HCC Screening Remain Unclear

Benefits of HCC Screening Remain Unclear

The benefits of hepatocellular carcinoma screening are unclear in patients with chronic liver disease.

Vitamin D May Lower Liver Cancer Risk

Vitamin D May Lower Liver Cancer Risk

A new study in Western Europeans shows that vitamin D lowers the risk of developing hepatocellular carcinoma.

Antivirals May Protect HBV Patients from Liver Cancer

Antivirals May Protect HBV Patients from Liver Cancer

Researchers have found that antiviral therapy may be successful in preventing hepatitis B virus from developing into the most common form of liver cancer, hepatocellular carcinoma.

AFP Detects Liver Cancer in Patients Without HCV

AFP Detects Liver Cancer in Patients Without HCV

Measurement of α-fetoprotein detects hepatocellular carcinoma most accurately in patients without hepatitis C virus infection.

Updated Results Announced for ThermoDox Use for HCC

Updated Results Announced for ThermoDox Use for HCC

Celsion announced updated results from its HEAT Study post-hoc analysis which examined the use of ThermoDox, a heat-activated liposomal encapsulation of doxorubicin, in combination with radiofrequency ablation (RFA) for the treatment of hepatocellular carcinoma (HCC).

Lipiodol Earns FDA Approval for Tumor Imaging in HCC

Lipiodol Earns FDA Approval for Tumor Imaging in HCC

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The FDA has approved Guerbet's Lipiodol (ethiozed oil) injection for imaging of hepatocellular carcinoma tumors

Drinking More Coffee May Lower Liver Cancer Risk

Drinking More Coffee May Lower Liver Cancer Risk

Increased coffee consumption may reduce hepatocellular carcinoma risk across ethnicities, according to a study presented at the AACR Annual Meeting.

Novel Kinase Inhibitor Shows Efficacy in Patients with Advanced HCC Tumors Overexpressing AFP

Novel Kinase Inhibitor Shows Efficacy in Patients with Advanced HCC Tumors Overexpressing AFP

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LY2157299 monohydrate showed promising efficacy results in patients with advanced HCC tumors overexpressing AFP.

Everolimus Failed to Improve Survival in Advanced HCC

Everolimus Failed to Improve Survival in Advanced HCC

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Data indicate that everolimus did not improve overall survival in patients with advanced HCC following sorafenib failure.

Gastrointestinal Toxicity of Sorafenib

Gastrointestinal Toxicity of Sorafenib

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Sorafenib can be an effective treatment for a variety of cancers, but its use can come with significant GI side effects.

Anti-CLTA4 Immunotherapy Achieves Antitumor Effects in Small Study of Hepatitis C-Related Hepatocellular Carcinoma

Anti-CLTA4 Immunotherapy Achieves Antitumor Effects in Small Study of Hepatitis C-Related Hepatocellular Carcinoma

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Immunotherapy targeting the CLTA4 protein in HCV-related HCC demonstrated modest extended survival in a disease that has a high mortality rate.

Targeting Vascular Endothelial Growth Factor in Treatment of Hepatocellular Carcinoma

Targeting Vascular Endothelial Growth Factor in Treatment of Hepatocellular Carcinoma

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Despite HCC having a poor prognosis and high mortality, systemic antiangiogenesis therapies offer some hope to patients.

Creating a Multidisciplinary Hepatocellular Carcinoma Clinic Improves Survival

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Forming a multidisciplinary clinic for patients with HCC resulted in improved survival, likely due to more streamlined care and earlier diagnosis, found research presented at SSO 2013.

Survival After Radiofrequency Ablation Might be 'Comparable' to Resection for Liver Cancer

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Radiofrequency ablation might offer comparable survival rates when compared with liver surgery for patients with hepatocellular carcinoma.

Aspirin Use Associated with Lower Liver Cancer Risk and Chronic Liver Disease Mortality Rates

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Aspirin use, but not the use of other nonsteroidal anti-inflammatory drugs (NSAIDs), is associated with a reduced risk of developing hepatocellular carcinoma.

RSNA: DEB TACE Viable Treatment Option for Advanced Unresectable HCC

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Patients with advanced unresectable hepatocellular carcinoma have a higher median overall survival when treated with drug eluting bead transarterial chemoembolization.

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