Abnormal Liver Function Tests: Elevations in ALT and AST, Which Predominate Over Elevations of Alkaline Phosphatase (ALP), 5'-NT, and/or Gamma Glutamyltransferase (GGT)
If the diseases in the list below increase in severity, there may be findings suggestive of cirrhosis with or without hepatic failure:
Viral hepatitis, multiple forms (see chapters on Viral Hepatitis A, B, and C)
Suggested Additional Lab Testing
Total bilirubin and unconjugated bilirubin are markedly elevated in hepatic failure.
Prothrombin time is elevated as a result of decreased synthesis of coagulation factors.
Aminotransferase levels may increase and then decrease rapidly when there is significant and permanent loss of hepatocytes.
Serum creatinine may be elevated as evidence of hepatorenal syndrome.
Low blood glucose, elevated white blood cell (WBC) count, low platelet count, and low serum albumin are also common in hepatic failure.
Serum ceruloplasmin is low (90% of the serum copper is complexed to this protein).
Twenty-four-hour urinary copper excretion is elevated.
Liver function tests may be normal, but, as the disease progresses, abnormal values appear.
Serum copper is usually elevated but may be normal or low.
Hepatic copper concentration is markedly elevated because of the low amount of serum ceruloplasmin; an elevated hepatic copper concentration is highly indicative of Wilson disease.
Serum alpha-1-antitrypsin level is low.
Abnormal liver function tests are detectable in adults who suffer liver damage, but they may be normal in early stages of disease.
Liver biopsy can show characteristic red cytoplasmic granules demonstrable by a PAS stain of the liver. Hepatocellular carcinoma requires histopathologic examination of a liver biopsy for diagnosis.
Copyright © 2017, 2013 Decision Support in Medicine, LLC. All rights reserved.
No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The Licensed Content is the property of and copyrighted by DSM.
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- High Red Meat Intake and Cancer
- Complete Resection of Metastatic Soft Tissue Sarcoma Associated With Improved Disease-specific Survival
- The Role of Anti-PD-1 Immunotherapy in Advanced Triple-negative Breast Cancer
- The Challenges of Immunotherapy Re-challenge in Metastatic Melanoma
- FDA Approves Fulvestrant/Abemaciclib Combination for Breast Cancer
- FDA Expands Sunitinib Indication To Include Adjuvant Therapy for Renal Cell Carcinoma
- Ultrasonography May Detect Thyroid Cancer Growth Arrest, Negating Need for Treatment
- Does Education Level Predict PSA Screening and Prostate Cancer Survival?
- Unrelated HSCT, UCBT May Yield Similar Survival Outcomes in Acute Leukemia
- Minimal Residual Disease and Patient Genotype May Inform Relapse Risk Algorithms in ALL