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Skin Cancer

New Mechanism of Treatment Resistance in BRAF-Mutant Melanoma Identified

New Mechanism of Treatment Resistance in BRAF-Mutant Melanoma Identified

Researchers were able to increase sensitivity to vemurafinib in resistant melanoma cell lines by reactivating genes that are involved in cell division.

General Oncology Poor Sleep Quality Associated With Symptom Burden Among Phase 1 Trial Participants

Poor Sleep Quality Associated With Symptom Burden Among Phase 1 Trial Participants

Patients who slept poorly exhibited greater symptom burden and overall mood disturbance.

Chronic Lymphocytic Leukemia Sleep Cycle May Be a Causal Factor of Chronic Lymphocytic Leukemia

Sleep Cycle May Be a Causal Factor of Chronic Lymphocytic Leukemia

If these findings are confirmed, 1 logical policy initiative would be to limit rotating night shifts to less than 20 years in total.

General Oncology PAP Series: Patient Assistance Programs "Culprits" of Rising Drug Prices

PAP Series: Patient Assistance Programs "Culprits" of Rising Drug Prices

The federal government is investigating some drugmakers' relationships with the charities that run assistance programs.

Chronic Myeloid Leukemia ABCB1 Expression Associated With Response to Imatinib in Chronic Myeloid Leukemia

ABCB1 Expression Associated With Response to Imatinib in Chronic Myeloid Leukemia

Increase in ABCB1 mRNA expression may serve as a marker for patients likely to be resistant to imatinib.

Skin Cancer A Call for a New Collaboration to Cure Melanoma

A Call for a New Collaboration to Cure Melanoma

In the not-too-distant future, several new combination therapies are expected, and they should represent an improvement not only in effectiveness, but in safety as well.

Prostate Cancer Should We Abandon PSA Testing Or Make it More Targeted?

Should We Abandon PSA Testing Or Make it More Targeted?

Widespread contamination of the Prostate, Lung, Colorectal, and Ovary (PLCO) Cancer Screening Trial has reignited the debate around prostate-specific antigen testing.

Hematologic Cancers Age and Acute Myeloid Leukemia: A Review of Current Literature

Age and Acute Myeloid Leukemia: A Review of Current Literature

Dr Isabel Cunningham reviews and highlights important, recently published articles with recommendations for treating elderly patients with acute myeloid leukemia (AML).

Breast Cancer Psychological Stress Unlikely to Cause Breast Cancer

Psychological Stress Unlikely to Cause Breast Cancer

Results of a prospective study consisting of more than 105,000 women have shown "it is unlikely that stress is implicated in causation of breast cancer."

General Oncology Encrypting Protected Health Information for HIPAA Compliance

Encrypting Protected Health Information for HIPAA Compliance

Addressable doesn't mean optional: Having an implementation plan can be helpful in case of an audit.

Multiple Myeloma In Search of the Right Treatment Combinations for Multiple Myeloma

In Search of the Right Treatment Combinations for Multiple Myeloma

A pooled analysis of 3 combination drug regimens used to treat refractory/relapsed multiple myeloma reaffirms their safety, but does little to distinguish which approach works best.

Multiple Myeloma Multiple Myeloma: Risk and Benefit Profile Assessment May Improve Outcomes

Multiple Myeloma: Risk and Benefit Profile Assessment May Improve Outcomes

Identifying and preventing drug-related toxicities with new combination therapies are paramount for both outcomes and quality of life issues.

Side Effect Management Patient Preferences: More Complex Than Maximizing Survival Time

Patient Preferences: More Complex Than Maximizing Survival Time

Quantifications of quality of life or patient-reported outcomes will offer more information for treatment-planning discussions.

Prostate Cancer Robotic Surgery for Prostate Cancer May Not Improve Quality of Life

Robotic Surgery for Prostate Cancer May Not Improve Quality of Life

Sexual function scores do not appear to differ between the 2 groups at 6 weeks or 12 weeks post-surgery, and no significant differences were found for bowel quality of life or pathological outcomes.

General Oncology Evolutionary Logic May Aid the Development of Cancer Therapies

Evolutionary Logic May Aid the Development of Cancer Therapies

Humans can tolerate tumors in large or paired organs more easily than in small, critical organs, and the larger organs may therefore have evolved fewer mechanisms to defend against cancerous cells.

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