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Lung Cancer "Impressive" CNS Responses With Osimertinib Compared With Standard EGFR-TKIs in Patients With CNS Metastases at Baseline

"Impressive" CNS Responses With Osimertinib Compared With Standard EGFR-TKIs in Patients With CNS Metastases at Baseline

A preplanned exploratory analysis in a subset of patients from the phase 3 FLAURA study with CNS metastases at baseline shows "impressive" clinical activity in the CNS.

Prostate Cancer Genetic Counseling Recommended for Advanced Prostate Cancer

Genetic Counseling Recommended for Advanced Prostate Cancer

A new white paper emphasizes the benefits of germline testing.

General Oncology Cancer Chemotherapeutics in Rheumatoid Arthritis: A Complex Connection

Cancer Chemotherapeutics in Rheumatoid Arthritis: A Complex Connection

Research is still needed to explore the association between cancer chemotherapeutics and rheumatoid arthritis.

Skin Cancer Predicting Response to Immunotherapy in Late-Stage Melanoma

Predicting Response to Immunotherapy in Late-Stage Melanoma

A new model has the potential to identify patients with melanoma who could benefit from treatment with checkpoint inhibitors.

General Oncology Oncology Community Expresses Concern About Medicare Advantage Step-Therapy Policy

Oncology Community Expresses Concern About Medicare Advantage Step-Therapy Policy

More than 90 medical societies have called on the US government to reverse a policy allowing step therapy under Medicare Advantage.

Chronic Myeloid Leukemia Progressive Telomere Shortening: An Epigenetic Biomarker of Chronic Myeloid Leukemia

Progressive Telomere Shortening: An Epigenetic Biomarker of Chronic Myeloid Leukemia

Progressive telomere shortening during successive cell divisions is thought to contribute to phase transition in chronic myeloid leukemia.

Breast Cancer Identifying Gene Variants Involved in Radiotherapy Toxicity Risk: A Q&A With Benjamin Smith, MD

Identifying Gene Variants Involved in Radiotherapy Toxicity Risk: A Q&A With Benjamin Smith, MD

Genomics could guide the decision about whether a patient should undergo implant reconstruction or autologous tissue-based reconstruction.

General Oncology FDA Guidance: Expansion Cohort Trials Expected to Modernize Oncology Trials

FDA Guidance: Expansion Cohort Trials Expected to Modernize Oncology Trials

There is a push to create innovative adaptive trial designs that include more patients and, subsequently, more generalizable data.

Breast Cancer Surgeon Attitudes May Influence Genetic Testing for Patients With Breast Cancer

Surgeon Attitudes May Influence Genetic Testing for Patients With Breast Cancer

The likelihood of a patient with breast cancer receiving genetic analysis more than doubled if she went to a surgeon with a high propensity for ordering such tests.

Lymphoma Liquid Biopsy May Predict Response to Therapy in Diffuse Large B-Cell Lymphoma

Liquid Biopsy May Predict Response to Therapy in Diffuse Large B-Cell Lymphoma

Circulating tumor DNA levels measured as early as 3 weeks post-therapy may provide clues about long-term outcomes in this lymphoma subtype.

Renal Cell Carcinoma Robotic Partial Nephrectomy Compared With Open, Laparoscopic Partial Nephrectomy

Robotic Partial Nephrectomy Compared With Open, Laparoscopic Partial Nephrectomy

A meta-analysis compared outcomes between the use of partial nephrectomy using a robotic surgical approach and open or laparoscopic partial nephrectomy.

Skin Cancer Exploring the Role of Immunotherapy in Melanoma Brain Metastases

Exploring the Role of Immunotherapy in Melanoma Brain Metastases

Although checkpoint inhibitors are active against melanoma-linked brain metastases, researchers are interested in exploring combination approaches.

Renal Cell Carcinoma Clues from DNA Repair Mechanisms Could Drive Novel Therapeutic Strategies

Clues from DNA Repair Mechanisms Could Drive Novel Therapeutic Strategies

Metabolites from the Krebs cycle were found to suppress the DNA-repair pathway required for the preservation of genomic integrity.

Lung Cancer Researchers Use Artificial Intelligence to Predict Patient Survival from Pathology Images in Lung Cancer

Researchers Use Artificial Intelligence to Predict Patient Survival from Pathology Images in Lung Cancer

Artificial intelligence techniques are being employed to build complex new multivariate prognostic models for patients with lung cancer and other malignancies.

Lymphoma Obinutuzumab in Follicular Lymphoma

Obinutuzumab in Follicular Lymphoma

Many patients with follicular lymphoma will be asymptomatic and present with variable cervical, axillary, and inguinal adenopathy.

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