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Chronic Lymphocytic Leukemia

Novel Targeted Agents For First-line CLL Treatment

Novel Targeted Agents For First-line CLL Treatment

Research is needed to determine which targeted agents should be used in young, fit patients and elderly unfit patients, and which regimens should be used first.

Skin Cancer SN-MMR for Stratification of SNB-positive Melanoma

SN-MMR for Stratification of SNB-positive Melanoma

SN-MMR was strongly associated with OS, melanoma-specific survival, and DFS among patients with a positive sentinel node biopsy.

Prostate Cancer Radiogenomics: Biomarkers for Prostate Cancer Radiotherapy Outcomes

Radiogenomics: Biomarkers for Prostate Cancer Radiotherapy Outcomes

Researchers are making progress in the search for biomarkers that can help identify which patients are most likely to benefit from radiotherapy.

Chronic Myeloid Leukemia Ponatinib: Black Box Warning and Drug Interactions

Ponatinib: Black Box Warning and Drug Interactions

If a patient develops any adverse event while on ponatinib, clinicians should perform a risk-benefit analysis before deciding whether to continue treatment.

Prostate Cancer Metastatic Prostate Cancer to the Gastrointestinal Tract

Metastatic Prostate Cancer to the Gastrointestinal Tract

Rarely, patients with prostate cancer will develop metastases to the gastrointestinal tract, which limit treatment options.

Multiple Myeloma MGUS: Determining Significance in Multiple Myeloma

MGUS: Determining Significance in Multiple Myeloma

MGUS may progress to multiple myeloma, AL amyloidosis, Waldenstrom's macroglobulinemia, or lymphoma. But not all cases progress to malignancy.

Lung Cancer ERCC1: Signals of Needed Research

ERCC1: Signals of Needed Research

Challenges persist in identifying predictive biomarkers for targeted chemotherapy, but new technologies offer potential.

Chronic Myeloid Leukemia TKI Discontinuation and Chronic Myeloid Leukemia

TKI Discontinuation and Chronic Myeloid Leukemia

TKIs offer the possibility of durable responses for patients with CML, though it is unclear whether discontinuation is feasible.

General Oncology Vitamin D and Cancer: An Unclear Relationship

Vitamin D and Cancer: An Unclear Relationship

According to the National Cancer Institute, there are not enough available data to establish whether taking vitamin D can prevent cancer.

Lung Cancer Non-small Cell Lung Cancer: Cisplatin-etoposide vs Carboplatin-paclitaxel

Non-small Cell Lung Cancer: Cisplatin-etoposide vs Carboplatin-paclitaxel

A recent review suggests that cisplatin-etoposide and carboplatin-paclitaxel regimens are comparable in efficacy.

General Oncology Basket Trials: Advantages and Limitations

Basket Trials: Advantages and Limitations

Basket trials offer a cost-effective option to evaluate targeted agents in multiple malignancies, but it is important to be aware of their limitations.

Gynecologic Cancer Obesity-driven Endometrial Cancer Raises Need for Intervention

Obesity-driven Endometrial Cancer Raises Need for Intervention

In women, the association between obesity and endometrial cancer is stronger than in any other type of cancer.

General Oncology A Year in Review: Reflections on Successes and Shortcomings

A Year in Review: Reflections on Successes and Shortcomings

Cancer Therapy Advisor's oncology editor discusses advances in oncology in 2016.

Prostate Cancer GATA2 in Prostate Cancer: A Promising Biomarker

GATA2 in Prostate Cancer: A Promising Biomarker

The pioneer transcription factor GATA2 has been implicated in prostate tumorigenesis, tumor aggressiveness, treatment resistance, and metastasis, making it a promising biomarker.

General Oncology Gender and Cost-related Medication Non-adherence

Gender and Cost-related Medication Non-adherence

Less than 8% of men and more than 12% of women reported CRN; an analysis found that CRN prevalence was highest for uninsured survivors and lowest for Medicare recipients.

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