Leukemia

FDA Approves Ivosidenib for <i>IDH1</i>-Mutated Relapsed/Refractory Acute Myeloid Leukemia

FDA Approves Ivosidenib for IDH1-Mutated Relapsed/Refractory Acute Myeloid Leukemia

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Ivosidenib is the first-in-class FDA approval for IDH1 mutation-harboring acute myeloid leukemia.

Clinical Stage at First Response May Predict Outcomes in Chronic Lymphocytic Leukemia

Clinical Stage at First Response May Predict Outcomes in Chronic Lymphocytic Leukemia

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Clinical stage determined by the Binet staging system could be an accurate response surrogate among patients with chronic lymphocytic leukemia.

Research Indicates Imatinib Is Effective in Pediatric Patients With Chronic Phase CML

Research Indicates Imatinib Is Effective in Pediatric Patients With Chronic Phase CML

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A large, long-term study found a 97% event-free survival rate at 18 months.

2-Year Consolidation with Nilotinib Leads to High Rate of Treatment-Free Remission in CML

2-Year Consolidation with Nilotinib Leads to High Rate of Treatment-Free Remission in CML

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For the single-treatment STAT2 phase 2 study, researchers enrolled 96 Japanese patients with chronic myeloid leukemia who had achieved a deep molecular response during the consolidation phase of treatment with nilotinib.

Researchers Pinpoint Factors Associated With the Development of Acute Myeloid Leukemia

Researchers Pinpoint Factors Associated With the Development of Acute Myeloid Leukemia

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Individuals at high risk of developing AML can be identified years before symptoms appear, a new study reports.

Enasidenib Monotherapy May Be Effective in Elderly Patients with IDH2-Mutated AML

Enasidenib Monotherapy May Be Effective in Elderly Patients with IDH2-Mutated AML

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Investigators sought to evaluate the efficacy of enasidenib among older patients with untreated acute myeloid leukemia, a population that is associated with poor therapeutic outcomes.

Recurrence-Free Survival May Be Sustainable After De-Escalation or Stoppage of TKI Therapy in CML

Recurrence-Free Survival May Be Sustainable After De-Escalation or Stoppage of TKI Therapy in CML

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Disease recurrence remained low among patients with CML who reduced or discontinued TKI therapy after achieving major response.

Obinutuzumab Plus Chlorambucil May Improve Survival Outcomes in Chronic Lymphocytic Leukemia

Obinutuzumab Plus Chlorambucil May Improve Survival Outcomes in Chronic Lymphocytic Leukemia

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Researchers randomly assigned previously untreated patients with CD20-positive CLL to receive obinutuzumab plus chlorambucil, rituximab plus chlorambucil, or chlorambucil alone.

In Vitro, In Vivo Studies Show Efficacy of Novel Compound CAR-T Therapy in Acute Myeloid Leukemia

In Vitro, In Vivo Studies Show Efficacy of Novel Compound CAR-T Therapy in Acute Myeloid Leukemia

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The effect of CAR-T therapy in acute myeloid leukemia has yet to be fully explored.

ENESTfreedom Study Reports Durable Treatment-Free Remission in Chronic Myeloid Leukemia After 96 Weeks

ENESTfreedom Study Reports Durable Treatment-Free Remission in Chronic Myeloid Leukemia After 96 Weeks

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Nearly half of patients with CML who achieved a deep molecular response following treatment with nilotinib remained in remission for 96 weeks.

Ibrutinib Monotherapy May Improve Survival in Deletion p17 Chronic Lymphocytic Leukemia

Ibrutinib Monotherapy May Improve Survival in Deletion p17 Chronic Lymphocytic Leukemia

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CLL/SLL characterized by del(17p) — a cytogenetic abnormality that develops over the course of the disease — is difficult to treat and responds very poorly to chemoimmunotherapy.

Bosutinib May Be Effective As First-Line Therapy in Chronic-Phase Chronic Myeloid Leukemia

Bosutinib May Be Effective As First-Line Therapy in Chronic-Phase Chronic Myeloid Leukemia

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Bosutinib is a dual Src/Abl tyrosine kinase inhibitor approved for newly diagnosed CP-CML and relapsed/refractory CML.

Nilotinib May Lead to Increased Rates of Treatment-Free Remission in Chronic-Phase CML

Nilotinib May Lead to Increased Rates of Treatment-Free Remission in Chronic-Phase CML

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Data from a previous study supports treatment-free remission as a new treatment goal for patients with chronic-phase chronic myeloid leukemia.

Chronic Myeloid Leukemia and Gastrointestinal Cancer Risk—In the Clinic

Chronic Myeloid Leukemia and Gastrointestinal Cancer Risk—In the Clinic

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There are some clinical data to support a potential for increased risk of additional solid organ malignancies in patients with CML.

Sex Hormone Levels Significantly Affect Treatment-Free Survival in Chronic Lymphocytic Leukemia

Sex Hormone Levels Significantly Affect Treatment-Free Survival in Chronic Lymphocytic Leukemia

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Men have approximately double the incidence rate, are more likely to have progressive and treatment-resistant disease, and have a poorer prognosis compared with women with CLL.

Pediatric CML: Life-Long Considerations With TKI Therapy

Pediatric CML: Life-Long Considerations With TKI Therapy

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Because most patients with CML are adults, there are no established treatment guidelines and many clinicians apply adult guidelines to their pediatric patients.

Nilotinib May Improve Rate of Deep Molecular Response in Chronic Myeloid Leukemia

Nilotinib May Improve Rate of Deep Molecular Response in Chronic Myeloid Leukemia

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Previous studies have shown that first-line therapy with nilotinib, as well as switching to nilotinib after prolonged imatinib, may lead to higher rates of deep molecular response in chronic myeloid leukemia.

Deep Molecular Response May Allow TKI-therapy Discontinuation in Chronic Myeloid Leukemia

Deep Molecular Response May Allow TKI-therapy Discontinuation in Chronic Myeloid Leukemia

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Targeted therapies among patients with chronic myeloid leukemia have improved over time, leading to patients achieving high rates of deep molecular response — a prerequisite criteria for tyrosine kinase inhibitor discontinuation.

Low-dose Dasatinib May Be Effective as Frontline Therapy in Chronic-phase Chronic Myeloid Leukemia

Low-dose Dasatinib May Be Effective as Frontline Therapy in Chronic-phase Chronic Myeloid Leukemia

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Dasatinib 100 mg is currently approved for chronic myeloid leukemia but has been associated with high rates of adverse events.

AML: Somatic Mutation Clearance May Be Prognostic for Survival

AML: Somatic Mutation Clearance May Be Prognostic for Survival

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Researchers determined 3 levels of somatic mutation clearance based on VAF of residual mutations at CR.

Leukemia Treatment Regimens: Acute Myeloid Leukemia (AML)

Get the latest treatment regimens for acute myeloid leukemia (AML), such as induction therapy, consolidation therapy, and more.

Infections: A Cause for Concern Among Patients With CLL

Infections: A Cause for Concern Among Patients With CLL

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Patients with CLL may have both disease-associated and systemic treatment-associated immune dysfunction, leaving them vulnerable to infection.

FDA Grants Priority Review to Duvelisib for CLL/SLL and Follicular Lymphoma

FDA Grants Priority Review to Duvelisib for CLL/SLL and Follicular Lymphoma

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The FDA is reviewing a New Drug Application, which is requesting full approval for CLL/SLL and accelerated approval for follicular lymphoma.

Measurable Residual Disease After Induction May Predict Outcomes in Acute Myeloid Leukemia

Measurable Residual Disease After Induction May Predict Outcomes in Acute Myeloid Leukemia

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Findings from previous studies suggests that multiparameter flow cytometric minimal residual disease may be used to predict outcomes in acute myeloid leukemia.

Identifying Treatment Failure in Patients With Chronic Myeloid Leukemia

Identifying Treatment Failure in Patients With Chronic Myeloid Leukemia

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One study's results may be especially relevant for patients eligible for treatment discontinuation.

In Focus: Voxtalisib for CLL and B-Cell Lymphomas

In Focus: Voxtalisib for CLL and B-Cell Lymphomas

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Voxtalisib is a potent inhibitor of 4 PI3K isoforms (p110α, p110β, p110γ, and p110δ) and a weaker inhibitor of mTOR.

FDA Approves Nilotinib for Pediatric Patients With CML

FDA Approves Nilotinib for Pediatric Patients With CML

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Patients one year or older are now eligible to receive the drug.

CLL: Venetoclax Plus Rituximab Improves 2-Year PFS

CLL: Venetoclax Plus Rituximab Improves 2-Year PFS

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Patients in the venetoclax arm had a grade 3 or 4 tumor lysis syndrome rate of 3.1%.

Patients with Chronic Myeloid Leukemia at Increased Risk of Secondary Cancers

Patients with Chronic Myeloid Leukemia at Increased Risk of Secondary Cancers

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Recently published findings suggest that patients with CML, particularly men, have a 30% higher risk of developing secondary cancers; however the cause of this increased risk is unclear.

Molecular Response and Sokal Score Associated with Treatment-free Remission Duration in CML

Molecular Response and Sokal Score Associated with Treatment-free Remission Duration in CML

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A subset of patients with chronic-phase CML in the ENESTfreedom study maintained treatment-free remission for at least 96 weeks after being treatment with frontline nilotinib.

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