Longitudinal Changes in Depression Symptoms Linked With Survival in Lung Cancer

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Longitudinal changes in depression symptoms were associated with differences in mortality among patients with lung cancer.
Longitudinal changes in depression symptoms were associated with differences in mortality among patients with lung cancer.

Longitudinal changes in depression symptoms were associated with differences in mortality among patients with lung cancer, according to a study published in the Journal of Clinical Oncology.1

In a prospective, observational study, researchers evaluated data from 1790 patients with lung cancer through the Cancer Care Outcomes Research and Surveillance Consortium.

Patients were given the 8-item Center for Epidemiologic Studies Depression scale screening test at diagnosis and 12 months' follow-up to determine longitudinal changes and their impact on survival.

Among the observed patients, 681 had depression symptoms at baseline and 105 developed new-onset depression symptoms while undergoing treatment. Depression symptoms were associated with a 17% increased risk of mortality.

After comparing longitudinal changes in depression symptoms from baseline to follow-up using patients with “never-depression symptoms” as a reference, the researchers found that the hazard ratio was 1.50 for patients with new-onset depression symptoms, 1.02 for those with depression symptom remission, and 1.42 for those with persistent depression symptoms.

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Depression symptoms were associated with increased mortality among patients with early-stage disease but not late-stage disease at baseline, while they were associated with mortality in both stages at follow-up.

Reference

  1. Sullivan DR, Forsberg CW, Ganzini L, et al. Longitudinal changes in depression symptoms and survival among patients with lung cancer: a national cohort assessment. J Clin Oncol. 2016 Oct 3. doi: 10.1200/JCO.2016.66.8459. [Epub ahead of print.]

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