Similar Incidence of Rash Regardless of Skin Treatment in NSCLC Treated With Erlotinib

Share this content:
Incidence of rash among patients with non-small cell lung cancer treated with erlotinib may not differ based on prophylactic skin treatment.
Incidence of rash among patients with non-small cell lung cancer treated with erlotinib may not differ based on prophylactic skin treatment.

Incidence of rash among patients with advanced non-small cell lung cancer (NSCLC) treated with erlotinib may not differ based on prophylactic skin treatment, according to a study published in the Journal of Clinical Oncology.1

Researchers led by Barbara Melosky, MD, of the British Columbia Cancer Agency in Vancouver randomly assigned 150 patients to prophylactic minocycline, reactive treatment, or not treatment unless severe.

They measured for rash incidence and severity, time to maximal rash, time to resolution, and overall survival among the 3 groups.

Incidence of skin toxicity was found to be 84% regardless of treatment option.

Grade 3 rash was found to be significantly higher in patients who received no treatment, while treatment with minocycline significantly extended time to the most severe grade of rash.

RELATED: Genotype-Guided Dose of Fluoropyrimidine May Decrease Toxicity

While overall survival was not significantly different between the groups, prophylactic and reactive treatments were found to have a longer overall survival than those who received no treatment.

“Prophylactic minocycline and reactive treatment are both acceptable options for the necessary treatment of erlotinib-induced rash in the second- or third-line setting of metastatic NSCLC,” the authors concluded.

Reference

  1. Melosky B, Anderson H, Burkes RL, et al. Pan Canadian Rash Trial: A Randomized Phase III Trial Evaluating the Impact of a Prophylactic Skin Treatment Regimen on Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor–Induced Skin Toxicities in Patients With Metastatic Lung Cancer [published online ahead of print November 16, 2015]. J Clin Oncol. doi: 10.1200/JCO.2015.62.3918

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters