Further Research Required for Treatment of HER2-positive Patients With NSCLC who Progress Following EGFR TKIs

Share this content:
Results of the first multicenter observational study reporting the outcomes of therapies of patients with non-small cell lung cancer.
Results of the first multicenter observational study reporting the outcomes of therapies of patients with non-small cell lung cancer.

The results of the first multicenter observational study reporting the outcomes of therapies of patients with epidermal growth factor receptor (EGFR)-positive non-small cell lung cancer in a “real-life Caucasian EGFR-mutated population” have been released, and they highlight the need for further research about new treatment strategies in this patient population.1

Response rates to first-line treatment with EGFR tyrosine kinase inhibitors decline after 9 to 12 months as patients develop resistance. No optimal therapy has been established as a second-line option.

Investigators sought to describe the percentage of EGFR-mutated patients who progressed to second-line therapy after treatment with EGFR tyrosine kinase inhibitors, assessing the type, objective response rate, progression-free and overall survival, and safety of second-line treatment. The study's second objective was to determine the efficacy of first-line treatment.

A total of 312 patients were included in the study. EGFR exon 19 deletion and L858R were the most common mutations, occurring in 59.6% and 31.1% of patients, respectively.

A total of 274 patients (95.1%) received any form of second-line therapy, including best supportive care. One hundred sixty-three patients received second-line systemic therapy with an overall response rate of 20.9% (95% CI, 14.62 – 27.10), a median progression-free survival and overall survival of 4.7 (95% CI, 3.81 – 5.26) and 24.5 (95% CI, 21.65 – 27.37) months, respectively.

RELATED: Geriatric Assessment for Older Patients With Lung Cancer Provides No Survival Advantage

In regard to safety, grade 3–4 hematological and non-hematological toxicities were reported in 9% and 6.3% of 144 patients treated with chemotherapy while non-hematological toxicity was reported in 4 cases of the 17 patients receiving second-line targeted therapies. 

Reference

  1. Vavalà T, Follador A, Tiseo M, et al. BE-POSITIVE: beyond progression after tyrosine kinase inhibitor in EGFR- positive non small cell lung cancer patients [article in press]. Lung Cancer. doi: 10.1016/j.lungcan.2016.02.011.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters