Trial Shows Noncompliance With Brain Imaging Guidelines in NSCLC

Share this content:
Wide variation in use among centers suggests a lack of adherence or knowledge about the recommendations for non-small cell lung cancer patients.
Wide variation in use among centers suggests a lack of adherence or knowledge about the recommendations for non-small cell lung cancer patients.

Although the Choosing Wisely recommendations from the Society of Thoracic Surgeons are against brain imaging in asymptomatic patients with non-small cell lung cancer, wide variation in use among centers suggests a lack of adherence or knowledge about the recommendations, according to an article published online ahead of print in Chest.1

Researchers in this study sought to describe the use of brain imaging and to identify variables associated with it among National Lung Screening Trial (NLST) participants. A total of 643 patients with clinical stage 1 non-small cell lung cancer were identified.

Of those, 12% of patients had received at least one brain imaging study. Of 1.1% of patients who were upstaged to stage 4 disease, two underwent imaging and neither had brain metastasis.

RELATED: FDA Expands Indication for Optune Device for Newly Diagnosed Glioblastoma

Researchers found high frequency variation among enrollment centers (0% to 80%). Multivariate analysis revealed that primary tumor size >20 mm (OR, 2.50; 95% CI, 1.50-4.16; P<.001) and age 65 to 69 (OR, 2.78; 95% CI, 1.38-5.57; P<.01) were linked to greater use of imaging.

Researchers concluded that one in eight NLST patients with stage 1A non-small cell lung carcinoma underwent brain imaging, but no proof of intracranial metastases was discovered.

Reference

  1. Balekian AA, Fisher JM, Gould MK. Brain imaging for staging of patients with clinical stage IA non-small cell lung cancer in the National Lung Screening Trial: adherence with recommendations from the Choosing Wisely campaign [published online ahead of print September 10, 2015]. Chest. doi: 10.1378/chest.15-1140.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters