Lung Cancer

Biomarker-Based Blood Test May Extend Reach of CT Screening for Certain Lung Cancers

Biomarker-Based Blood Test May Extend Reach of CT Screening for Certain Lung Cancers

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Although they fall outside official testing guidelines for lung cancer, people who have smoked at all in their lifetime could still be at risk for the disease. Researchers propose a biomarker test for 4 proteins could identify more individuals that could benefit from subsequent screening.

Is Genomic Medicine Failing Minority Patients?

Is Genomic Medicine Failing Minority Patients?

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Racial minorities are poorly represented in genomic research databases, raising important questions about whether or not all patients will benefit equally from advances in precision oncology.

Fulvestrant Plus Erlotinib May Improve Progression-Free Survival in <I>EGFR</I> Wild-Type NSCLC

Fulvestrant Plus Erlotinib May Improve Progression-Free Survival in EGFR Wild-Type NSCLC

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Recent findings identified interactions between the EGFR and estrogen receptor signaling pathways, which could potentially modify outcomes in non-small cell lung cancer.

Risk of Brain Metastasis in Colorectal Cancer Dependent on Tumor Location and Other Metastatic Sites

Risk of Brain Metastasis in Colorectal Cancer Dependent on Tumor Location and Other Metastatic Sites

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In patients with colorectal cancer, rectal tumors and lung metastasis appeared to be linked to an elevated risk for brain cancer.

<i>ARID1A</i> Mutations Might Predict Tumor Response to Immunotherapy

ARID1A Mutations Might Predict Tumor Response to Immunotherapy

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New findings bolster the case for the predictive utility of ARID1A mutations.

Liquid Biopsies and Cancer Detection: New Test Assesses Levels of Circulating Proteins for Early-Stage Diagnosis

Liquid Biopsies and Cancer Detection: New Test Assesses Levels of Circulating Proteins for Early-Stage Diagnosis

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A new test has been shown to be capable of identifying eight different cancers by assessing levels of circulating proteins along with mutations in cell-free DNA.

Understanding Telomerase: Higher Quality Images Give Insight Into Developing New Agents for Inhibition

Understanding Telomerase: Higher Quality Images Give Insight Into Developing New Agents for Inhibition

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Telomerase plays a crucial role in tumor proliferation, and a better understanding of its structure will pave the way for new drug development.

Upfront Next-Generation Sequencing Is Faster, More Cost-Effective in Metastatic NSCLC

Upfront Next-Generation Sequencing Is Faster, More Cost-Effective in Metastatic NSCLC

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The researchers argue that upfront next-generation sequencing should be the new standard of care.

Efficacy and Hyperemesis Syndrome Associated With Cannabinoid Use in Cancers ― In the Clinic

Efficacy and Hyperemesis Syndrome Associated With Cannabinoid Use in Cancers ― In the Clinic

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Many clinical trials and systematic reviews note that the use of cannabinoids also comes with adverse events, including a clinical entity that has been gaining evidence in the literature over the last decade called cannabinoid hyperemesis syndrome.

Role of <i>BRAF</i> Mutations in Non-Small Cell Lung Cancer Still Emerging, Evolving

Role of BRAF Mutations in Non-Small Cell Lung Cancer Still Emerging, Evolving

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"BRAF-mutated NSCLC represents an emerging targetable entity among the scenario of oncogene-driven NSCLC."

Bifunctional Immunotherapy M7824 For Advanced NSCLC, HPV-Associated Cancers

Bifunctional Immunotherapy M7824 For Advanced NSCLC, HPV-Associated Cancers

James L. Gulley, MD, PhD, FACP, discusses his findings at ASCO 2018 meeting.

Gefitinib Plus Platinum-Doublet Chemotherapy May Improve Overall Survival in <i>EGFR</i>-Positive NSCLC

Gefitinib Plus Platinum-Doublet Chemotherapy May Improve Overall Survival in EGFR-Positive NSCLC

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EGFR tyrosine kinase inhibitor monotherapy has improved progression-free survival (PFS) but not overall survival (OS) compared with chemotherapy in non-small cell lung cancer.

Bevacizumab Plus Erlotinib May Be a New Standard of Care in Non-Small Cell Lung Cancer

Bevacizumab Plus Erlotinib May Be a New Standard of Care in Non-Small Cell Lung Cancer

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Recent studies have explored the potential of combination therapy with EGFR-TKIs and VEGF-inhibitors for patients with EGFR-positive non-small cell lung cancer.

Cemiplimab for Cutaneous Squamous Cell Carcinoma

Cemiplimab for Cutaneous Squamous Cell Carcinoma

Danny Rischin, MBBS, FRACP, MD, speaks at the American Society of Clinical Oncology (ASCO) 2018 meeting.

Phase II Data of Tepotinib for Non-Small Cell Lung Cancer

Phase II Data of Tepotinib for Non-Small Cell Lung Cancer

Enriqueta Felip, MD, PhD, discusses her findings at the ASCO 2018 meeting in Chicago.

Web-Based Monitoring Resulted in Longer Overall Survival for Patients in Lung Cancer

Web-Based Monitoring Resulted in Longer Overall Survival for Patients in Lung Cancer

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Previous findings showed a 7 month median overall survival benefit (P = .002) for patients with lung cancer given web-mediated follow-up.

Lung Cancer Screening Rates Inadequate in United States Despite USPSTF Recommendations

Lung Cancer Screening Rates Inadequate in United States Despite USPSTF Recommendations

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Current literature reflects estimates, but not actual rates, of low-dose computed tomography adherence across the United States.

Can Oncolytic Viruses Improve Immunotherapies?

Can Oncolytic Viruses Improve Immunotherapies?

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Emerging evidence shows that injecting tumors directly into one tumor can trigger systemic antitumor immunity and immune attacks on untreated tumors elsewhere in the body.

Prophylactic Cranial Irradiation Reduces the Incidence of Brain Metastases in NSCLC

Prophylactic Cranial Irradiation Reduces the Incidence of Brain Metastases in NSCLC

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Some figures show that incidence of brain metastasis is approximately 30% 2 years after being diagnosed with non-small cell lung cancer.

Pembrolizumab and Chemotherapy Combination Significantly Improves PFS in NSCLC

Pembrolizumab and Chemotherapy Combination Significantly Improves PFS in NSCLC

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The phase 3 study found the combination effective, regardless of tumor proportion score.

Clonally Transmissible Cancers in Nature

Clonally Transmissible Cancers in Nature

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While a recent discovery of a series of communicable cancers has raised concerns, there has been no sign of readily transmittable cancer in people that could spread through a population the way the ones found in other species do.

Immunotherapy for Lung Cancer: Are Combination Regimens a Path Forward?

Immunotherapy for Lung Cancer: Are Combination Regimens a Path Forward?

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PD-1/PD-L1 ICI can offer remarkable benefits as first- and second-line treatments for NSCLC, but 80% of patients do not respond to immunotherapy, and many of those who do respond eventually see their cancers acquire drug resistance.

Timely Reporting of Palliative Care Needs Leads to More Appropriate End-of-Life Care in NSCLC

Timely Reporting of Palliative Care Needs Leads to More Appropriate End-of-Life Care in NSCLC

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Researchers accessed the French National Hospital registry and obtained the records of 64,950 patients who died of metastatic NSCLC between 2010 and 2013.

Asthma Inhalation Therapies

Asthma inhalation therapies including exercise induced bronchospasm (EIB) and asthma maintenance dosing.

Osimertinib Improves Quality-of-Life and Global Health Status in Non-Small Cell Lung Cancer

Osimertinib Improves Quality-of-Life and Global Health Status in Non-Small Cell Lung Cancer

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Non-small cell lung cancer largely remains incurable and is associated with high symptom burden and reduced quality of life.

The Hunt for Effective Anticancer Vaccines

The Hunt for Effective Anticancer Vaccines

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Researchers are hotly pursuing 2 distinct biological paths that show remarkable promise in the hunt for an effective anticancer vaccine.

Phase 1/2 Trial of CAR-T Cell Immunotherapy in Metastatic, Mesothelin-Expressing Cancer

Phase 1/2 Trial of CAR-T Cell Immunotherapy in Metastatic, Mesothelin-Expressing Cancer

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Researchers are evaluating whether CAR-T cell immunotherapy that targets mesothelin is safe and effective among patients with mesothelin-expressing tumors.

Mesothelioma Treatment Regimens

Access treatment options for mesothelioma in this detailed drug regimen, which includes agents such as pemetrexed + cisplatin and more.

HIV-Associated Cancers: A Paradigm Shift?

HIV-Associated Cancers: A Paradigm Shift?

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Many HIV-associated cancers develop with the help of oncoviruses — some of which are sexually transmitted.

CTCs May Not Have Genetic Changes Found in Primary Lung Tumors

CTCs May Not Have Genetic Changes Found in Primary Lung Tumors

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At surgery, blood samples were taken from 163 patients; whole genome sequencing and whole exome signaling were performed on detected CTCs.

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