In Focus: Bendamustine for Non-Hodgkin Lymphomas

Share this content:
Data support use of bendamustine for patients treated with several lines of therapy, but whether this drug should be used in the first line is open to question.
Data support use of bendamustine for patients treated with several lines of therapy, but whether this drug should be used in the first line is open to question.

Following its US Food and Drug Administration (FDA) approval in 2008 based on a single-arm phase 2 study (SDX-105-01; ClinicalTrials.gov Identifier: NCT00069758), bendamustine has emerged as the standard chemotherapy portion of the chemoimmunotherapy regimen used to treat non-Hodgkin lymphoma (NHL).1

Yet SDX-105-01 and 2 other studies — SDX-105-02 and SDX-105-03 (ClinicalTrials.gov Identifier: NCT00076349 and NCT00139841, respectively) — provide limited follow up for the long-term safety of bendamustine.1-3

In a retrospective analysis using patient-level data from the 3 studies, an analysis published in the British Journal of Haematology reported that after a median follow up of about 9 years, “no clear new safety signals attributable to bendamustine were identified,” and bendamustine did not appear to adversely affect stem cell collection (required for potential transplantation) or subsequent therapy.4

“With a follow up of nearly 10 years, this analysis confirms that bendamustine is an efficacious anti-lymphoma drug with a safety profile similar to what was observed in earlier studies,” corresponding author Peter Martin, MD, lymphoma service chief at Weill Cornell Medicine and New York-Presbyterian Hospital in New York, told Cancer Therapy Advisor.

Three Studies Provided Patient-level Data

For this analysis, data from 149 of the 245 patients from SDX-105-01, SDX-105-02, and SDX-105-03 were made available. In 2 of the studies (SDX-105-01 and SDX-105-03), bendamustine was provided as a single agent, while in SDX-105-02 bendamustine was provided in combination with rituximab.

Patients included in the analysis had relapsed or refractory follicular, small lymphocytic, marginal zone, mantle cell, transformed, or lymphoplasmacytic lymphoma and had received a median of 3 prior therapies, with a range of 1 to 8.

RELATED: Hodgkin Lymphoma: Risk-adapted Therapy Recommended

Patients treated with single-agent bendamustine (106) or the combination regimen (43) received a median of 6 cycles. Patients receiving bendamustine in combination received a dose of 90 mg/m2, while those receiving the single agent received a dose of 120 mg/m2 — all on days 1 and 2 of each treatment cycle.

Page 1 of 3

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters