Radiotherapy, No Treatment After ABVD Effective for Early-Stage Hodgkin's Lymphoma

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Early-stage Hodgkin's lymphoma and negative PET findings had good prognosis either with or without consolidation radiotherapy.
Early-stage Hodgkin's lymphoma and negative PET findings had good prognosis either with or without consolidation radiotherapy.

Although noninferiority of the strategy of no further treatment after chemotherapy with regard to progression-free survival was not observed, patients with early-stage Hodgkin's lymphoma and negative positron-emission tomography (PET) findings after three cycles of ABVD chemotherapy had a very good prognosis either with or without consolidation radiotherapy, a study published this week in The New England Journal of Medicine has shown.

Because it is unclear whether patients with early-stage Hodgkin's lymphoma and negative findings on PET after three cycles of ABVD require radiotherapy, researchers sought to assess the noninferiority of no further treatment versus involved-field radiotherapy.

Researchers enrolled 602 patients with newly diagnosed stage IA or IIA Hodgkin's lymphoma who received three cycles of ABVD followed by PET scanning.

Of those, 420 had negative findings and were randomly assigned 1:1 to the radiotherapy group or no further therapy.

RELATED: Milatuzumab Plus Veltuzumab Demonstrate Activity in B-Cell Non-Hodgkin Lymphoma

Results showed that the 3-year progression-free survival rates were 94.6% (95% CI: 86.9-94.8) and 90.8% (95% CI: 86.9-94.8) in the radiotherapy group and no further therapy group, respectively.

The absolute risk difference was -3.8 percentage points (95% CI: -8.8-1.3), which had to be more than 7 percentage points in order for no further treatment to be noninferior to radiotherapy.

Reference

  1. Radford J, Illidge T, Counsell N, et al. Results of a trial of PET-directed therapy for early-stage Hodgkin's lymphoma. N Engl J Med. 2015; 372:1598-1607.

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