Malignancies in Pregnancy Explored in Lancet Series

Share this article:

(ChemotherapyAdvisor) – Treatment of women diagnosed with cervical, ovarian, breast, and hematologic cancers in pregnancy is the focus of three articles published in The Lancet February 10. Up to 1 in 1,000 pregnancies is affected by cancer, and this number is expected to rise as women postpone pregnancy. The current trend is to preserve pregnancy wherever possible.

The first article explores issues around gynecological cancer, of which cervical and ovarian are the most common. Management of patients with cervical cancer is controversial and complex, the authors note, and should be discussed on a case-by-case basis “according to the tumor size, radiological findings, the term of pregnancy, and the patient's wishes.” For ovarian cancer, use of chemotherapy is possible in the second or third trimester.

The second article notes that breast cancer during pregnancy is not an emergency; therefore, time should be taken to determine a multidisciplinary approach. Both surgery and chemotherapy are possible, although radiation therapy is not generally advised. Termination of the pregnancy does not improve outcome for the mother and a normal-length pregnancy to avoid harm caused by premature birth should be the goal. The placenta should be examined for metastases; breastfeeding in the first few weeks after chemotherapy is not recommended.

Lymphoma is the fourth most common cancer in pregnancy, affecting one in 6,000 pregnancies, according to the third article. Non-Hodgkin lymphoma, acute leukemia, and other hematologic malignancies can also occur in pregnancy; all pose diagnostic and therapeutic challenges. This article emphasizes management should focus on survival of the mother and concludes that the scarcity of data underscores the need for extensive collaborative efforts to expand basic and clinical research.

The Lancet Series

Share this article:

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

CTA Community Poll

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs

More in General Oncology News

Factors in Late Hospice Admission for Cancer Identified

Factors in Late Hospice Admission for Cancer Identified

Late admission more likely for younger patients, married men, hematologic malignancies.

New Treatment Program May Help Patients With Cancer and Untreated Depression

New Treatment Program May Help Patients With Cancer ...

Nearly 3/4th of depressed cancer patients do not receive any form of treatment for their depression.

Medicaid Reimbursement Linked with Greater Cancer Screening Rate

Medicaid Reimbursement Linked with Greater Cancer Screening Rate

Changes to Medicaid reimbursements can improve cancer screening rates.