Patients With Myeloma Refractory to Induction with Novel Agents Have Poor Outcomes

Share this content:
The use of novel agents, such as lenalidomide and carfilzomib, has resulted in improved overall survival for patients with multiple myeloma.
The use of novel agents, such as lenalidomide and carfilzomib, has resulted in improved overall survival for patients with multiple myeloma.

Patients with multiple myeloma refractory to induction therapy in the current era of novel agents have poor outcomes compared with those achieving a partial response or better, according to a recent study published online ahead of print in the American Journal of Hematology.

The American Cancer Society estimates that nearly 27,000 Americans will be diagnosed with multiple myeloma in 2015, and more than 11,200 will die from the disease in the same year.

The use of novel agents, such as lenalidomide and carfilzomib, has resulted in improved overall survival for patients with multiple myeloma, but limited data demonstrating the impact of refractoriness to these agents when used as initial therapy exist.

For the study, researchers from the Mayo Clinic in Rochester, MN, sought to evaluate the survival difference between patients achieving at least a partial response to induction therapy and those were refractory to initial induction therapy.

Researchers analyzed data from 816 consecutive patients treated for multiple myeloma at their institution since 2006.

Results showed that median overall survival from the start of therapy was 7.6 years for responding patients vs 3.6 years for primary refractory patients (P<0.001). When only patients who received novel agents as part of induction therapy were included, the median overall survival was 7.9 years and 3.6 years, respectively (P<0.001).

RELATED: IMWG Revises International Staging System for Multiple Myeloma

The analysis demonstrated a median overall survival of not reached, 6.1, 6.4, and 4.2 years for patients achieving a complete response, very good partial response, partial response, or less than partial response, respectively.

The findings suggest that patients with multiple myeloma refractory to initial induction therapy should be studied further to assess predictors of resistance.

Reference

  1. Majithia N, Rajkumar SV, Lacy MQ, et al. Outcomes of primary refractory multiple myeloma and the impact of novel therapies. Am J Hematol. 2015. [epub ahead of print]. doi: 10.1002/ajh.24131.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters