During a plenary presentation at the 18th annual WCLC, researchers presented patient-reported outcomes, including health-related QoL, disease symptoms, and physical function, from the phase 3 PACIFIC trial.
Researchers randomly assigned 56 treatment-naive patients with advanced NSCLC to 3 cohorts: nivolumab plus gemcitabine and cisplatin, nivolumab plus pemetrexed and cisplatin, and nivolumab plus paclitaxel and carboplatin.
For this cross-sectional study, researchers collected the data of 1030 adult patients with advanced NSCLC from medical chart reviews and various patient questionnaires.
One-hundred and eight patients received cisplatin plus docetaxel in the control arm; 392 patients in the experimental arm received varying treatments according to BRCA1 mRNA expression levels.
Researchers evaluated survival and socioeconomic data from 1,150,722 patients with NSCLC to determine particular factors that may predict OS.
Researchers administered savolitinib 600 mg plus gefitinib 250 mg to 44 patients, of whom 6 were T790M-positive and 5 were T790M-negative.
Investigators randomly assigned 95 patients with ED-SCLC to receive pazopanib 800 mg daily or placebo.
Initial analysis of cohort G of KEYNOTE-021 at a median of 10.6 months showed that pembrolizumab significantly improved overall response rate and progression-free survival compared with pemetrexed/carboplatin alone.
Researchers analyzed the resistance biopsies and plasma specimens of 119 patients with T790M-positive NSCLC treated with osimertinib.
Researchers enrolled 248 patients who progressed on pemetrexed-based chemotherapy with or without bevacizumab to receive second-line anetumab ravtansine or vinorelbine.
Patients diagnosed with NSCLC between 2010 and 2013 had a median OS of 14.8 months compared with 12.4 months among patients diagnosed between 2004 and 2009.
Researchers randomly assigned 89 patients with NSCLC to the SLND arm, in which patients underwent standard lung resection with SLND, or to the BML arm, in which patients received SLND plus contralateral mediastinal lymphadenectomy.
Researchers analyzed the outcomes of 7060 patients with SCLC from the SEER database to determine the rates of new CEs among patients treated with chemotherapy plus RT or chemotherapy alone.
The purpose of this study was to compare the effectiveness of SABR with CRT in prolonging time to local failure in this patient population.
A previous study noted a $30 median 30-day TKI supply copayment for privately insured patients. The median out-of-pocket cost was $452 for the same supply among patients included in this study.
Gilteritinib inhibits the FLT3 mutations observed in up to one-third of patients with AML, FLT3 internal tandem duplication, and the FLT3 tyrosine kinase domain.
The number of treatment options — coupled with the sometimes-overaggressive therapies used — suggests a need for integration of the potential financial effects of missed work into patient counseling after a breast cancer diagnosis.
Custirsen inhibits clusterin production, which is associated with chemotherapy resistance; previous study suggested that custirsen may improve progression-free survival in this setting.
The FDA grants Priority Review to medications with the potential to significantly improve outcomes or safety in the treatment, diagnosis, or prevention of serious conditions compared with available treatments.
Osimertinib Granted Breakthrough Therapy Designation as First-line Treatment for EGFR-positive NSCLC
Osimertinib was previously approved as a second-line therapy for patients with NSCLC who progress after treatment with an EGFR TKI because of the EGFR T790M resistance mutation.
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