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First-line Immune Checkpoint Inhibition Cost-effective in Melanoma

First-line Immune Checkpoint Inhibition Cost-effective in Melanoma

First-line immune checkpoint inhibition is more cost-effective than chemotherapy for treatment-naïve, BRAF wild-type, stage IV melanoma.

Olaparib Improves PFS in BRCA-mutant Breast Cancer

Olaparib Improves PFS in BRCA-mutant Breast Cancer

Olaparib significantly prolonged progression-free survival compared with chemotherapy among patients with HER2-negative breast cancer.

Nivolumab Active in Squamous Cell Carcinoma of the Anal Canal

Nivolumab Active in Squamous Cell Carcinoma of the Anal Canal

Nivolumab was clinically active and well-tolerated among patients with treatment-refractory metastatic squamous cell carcinoma of the anal canal (SCCA).

Cyclophosphamide Reduction in Rhabdomyosarcoma

Cyclophosphamide Reduction in Rhabdomyosarcoma

Reducing the cyclophosphamide dose for a subset of patients with rhabdomyosarcoma may increase the risk of disease recurrence.

Safety of Active Surveillance for Small Renal Masses

Safety of Active Surveillance for Small Renal Masses

Active surveillance appears to be a safe alternative to primary intervention for selected patients with small renal masses.

Dual Immunotherapy Active vs Sunitinib for PD-L1+ Advanced RCC

Dual Immunotherapy Active vs Sunitinib for PD-L1+ Advanced RCC

Atezolizumab (Tecentriq) combined with bevacizumab (Avastin) demonstrated antitumor activity compared with sunitinib as first-line therapy.

Genomic Alterations in Metastatic Renal Cell Carcinoma

Genomic Alterations in Metastatic Renal Cell Carcinoma

Patients with metastatic renal carcinoma (mRCC) treated with post-frontline agents had increased genomic alterations.

Adjuvant BEP for 1 Cycle Safe, Efficacious for Testicular Cancer

Adjuvant BEP for 1 Cycle Safe, Efficacious for Testicular Cancer

Bleomycin, etoposide, and cisplatin (BEP) for 1 cycle after orchiectomy is associated with a similar 2-year recurrence rate as BEP.

Urothelial Carcinoma: Year in Review

Urothelial Carcinoma: Year in Review

Studies presented in the last year demonstrated a revolutionary role for immune checkpoint inhibitors.

Pembrolizumab Improves Survival and Quality of Life in Advanced Bladder Cancer

Pembrolizumab Improves Survival and Quality of Life in Advanced Bladder Cancer

Pembrolizumab following platinum-based chemotherapy was associated with significantly longer overall survival, fewer adverse events.

Bladder Cancer: Genomics May Predict Benefit from Neoadjuvant Chemotherapy

Bladder Cancer: Genomics May Predict Benefit from Neoadjuvant Chemotherapy

David J. McConkey, MD, PhD, described how genomics can affect the clinical management of patients with bladder cancer.

Bladder Cancer: Neoadjuvant Chemotherapy and Molecular Subtype

Bladder Cancer: Neoadjuvant Chemotherapy and Molecular Subtype

The clinical outcomes when using neoadjuvant chemotherapy for muscle-invasive bladder cancer vary by molecular subtype.

Chemo + Radiotherapy Efficacious in Muscle-invasive Bladder Cancer

Chemo + Radiotherapy Efficacious in Muscle-invasive Bladder Cancer

Adding chemotherapy with fluorouracil and mitomycin to radiotherapy improves locoregional control.

mCRPC: Full-length AR Copy Number Prognostic for Outcomes

mCRPC: Full-length AR Copy Number Prognostic for Outcomes

Full-length androgen receptor (AR-FL) copy number derived from circulating tumor cells detected using a liquid biopsy.

Adjuvant Trials in Post-radical Prostatectomy Prostate Cancer Are Feasible

Adjuvant Trials in Post-radical Prostatectomy Prostate Cancer Are Feasible

A phase 3 study presented at the 2017 Genitourinary Cancers Symposium demonstrated the feasibility of conducting adjuvant trials.

Novel Mutated Genes, Pathways in Prostate Cancer Identified

Novel Mutated Genes, Pathways in Prostate Cancer Identified

Researchers identified nearly 80 significantly mutated genes in prostate cancer, including many novel genes and pathways.

Decipher Genomic Classifier Prognostic for Metastasis, PCa-specific Mortality

Decipher Genomic Classifier Prognostic for Metastasis, PCa-specific Mortality

The Decipher genomic classifier obtained from biopsy samples was prognostic for distant metastases and prostate cancer-specific mortality.

Immunotherapy and the Future of Prostate Cancer Treatment

Immunotherapy and the Future of Prostate Cancer Treatment

Despite early failures, there may be a role for single-agent and combination immunotherapy for patients with prostate cancer.

Highest Genetic Risk Group Has 5-fold Higher Risk of Prostate Cancer

Highest Genetic Risk Group Has 5-fold Higher Risk of Prostate Cancer

The risk for developing prostate cancer is more than 5 times higher for men in the top 1% of the genetic risk score group.

Smoking May Increase Risk of Death in Patients With CML

Smoking May Increase Risk of Death in Patients With CML

By potentially affecting the disease biology of chronic myeloid leukemia (CML), smoking may increase the risk of death.

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