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PSA Testing Unchanged in Years After USPSTF Recommendation

PSA Testing Unchanged in Years After USPSTF Recommendation

Prostate-specific antigen (PSA) testing behavior did not significantly change in the years after a USPSTF recommendation against PSA screening.

Risk of Arrhythmias, Bleeding Higher With Ibrutinib Therapy

Risk of Arrhythmias, Bleeding Higher With Ibrutinib Therapy

Ibrutinib therapy carries a significantly higher risk of atrial fibrillation/flutter and all-grade bleeding compared with other treatments.

MRI May Be Effective Screening Test for Hepatocellular Carcinoma

MRI May Be Effective Screening Test for Hepatocellular Carcinoma

Magnetic resonance imaging (MRI) may be an effective tool for diagnosing hepatocellular carcinoma (HCC).

Prolonged Imatinib Therapy Linked With Deeper Molecular Response in CML-CP

Prolonged Imatinib Therapy Linked With Deeper Molecular Response in CML-CP

For patients with chronic myeloid leukemia, prolonged imatinib use helps achieve deeper molecular response with long-term treatment.

Study Emphasizes Importance of Skin Exams for Organ Transplant Recipients

Study Emphasizes Importance of Skin Exams for Organ Transplant Recipients

Nonwhite organ transplant recipients are at risk for developing non-melanoma skin cancer following transplantation.

TP53, MDM2 Alterations Linked to Cisplatin Resistance in Testicular Cancer

TP53, MDM2 Alterations Linked to Cisplatin Resistance in Testicular Cancer

TP53 and MDM2 alterations are associated with resistance to cisplatin and inferior progression-free survival among patients with metastatic germ cell tumors.

Alpha-fetoprotein Levels May Predict HCC Response to Ramucirumab

Alpha-fetoprotein Levels May Predict HCC Response to Ramucirumab

Alpha-fetoprotein (aFP) levels of at least 400 ng/mL predict patients with hepatocellular carcinoma (HCC) likely to respond to second-line ramucirumab.

Post-mastectomy Radiotherapy Reduces Risk for Locoregional Failure, Recurrence

Post-mastectomy Radiotherapy Reduces Risk for Locoregional Failure, Recurrence

Treatment with post-mastectomy radiotherapy (PMRT) reduces the risk for locoregional failure (LRF) recurrence and mortality.

Circulating Plasma Cells Predict Poor Prognosis in Multiple Myeloma

Circulating Plasma Cells Predict Poor Prognosis in Multiple Myeloma

The presence of circulating plasma cells (CPCs) predicts a worse prognosis for patients with multiple myeloma.

Response Rate Similar Between Low- and Standard-dose Ponatinib

Response Rate Similar Between Low- and Standard-dose Ponatinib

Response with low-dose ponatinib is similar to that of standard-dose ponatinib among patients with refractory chronic myeloid leukemia (CML).

Imatinib Less Beneficial for Patients With CML in Accelerated Phase

Imatinib Less Beneficial for Patients With CML in Accelerated Phase

Patients with chronic myeloid leukemia (CML) in accelerated phase may obtain less clinical benefit with first-line imatinib therapy.

Ibrutinib Linked With Favorable Survival, High Response Rate in CLL

Ibrutinib Linked With Favorable Survival, High Response Rate in CLL

Treatment with ibrutinib may be associated with favorable progression-free and overall survival as well as high overall response rate.

FDA Accepts NDA for Neratinib in HER2+ Early Stage Breast Cancer

FDA Accepts NDA for Neratinib in HER2+ Early Stage Breast Cancer

The FDA accepted a New Drug Application for neratinib for the extended treatment of patients with early HER2-positive breast cancer.

Dalantercept Monotherapy Study Misses Endpoint

Dalantercept Monotherapy Study Misses Endpoint

Treatment with single-agent dalantercept had favorable safety profile in recurrent or metastatic head and neck squamous cell carcinoma.

Bevacizumab Not Recommended in Adjuvant Colorectal Cancer Treatment

Bevacizumab Not Recommended in Adjuvant Colorectal Cancer Treatment

Bevacizumab should not be used with capecitabine as an adjuvant treatment for colorectal cancer.

Addition of Rituximab to Chemo Provides Survival Benefit in Acute Leukemia

Addition of Rituximab to Chemo Provides Survival Benefit in Acute Leukemia

The addition of rituximab to chemotherapy may benefit patients being treated for acute lymphoblastic leukemia (ALL).

Statins Linked to Improved Overall Survival in Multiple Myeloma

Statins Linked to Improved Overall Survival in Multiple Myeloma

In a large cohort of US veterans with multiple myeloma, statin therapy was associated with a decreased risk of all-cause and cancer-specific mortality.

Immunotherapy-related Pneumonitis More Common With Combo Therapy

Immunotherapy-related Pneumonitis More Common With Combo Therapy

Pneumonitis associated with PD-1/PD-L1 monoclonal antibodies is more common when given in combination with anti-CTLA-4 monoclonal antibodies.

Population Disparity in NCI Studies Still Needs Improvement

Population Disparity in NCI Studies Still Needs Improvement

Enrollment disparities in clinical trials improved between 1990 and 2012 for female and elderly patients with lung cancer.

G-CSF Linked With Some Reduction in Neutropenia-related Hospitalization

G-CSF Linked With Some Reduction in Neutropenia-related Hospitalization

Primary G-CSF was associated with low-to-modest benefit in lowering risk for neutropenia-related hospitalization.

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