In Pancreatic Cancer, Blood Neutrophil-Lymphocyte Ratio Predicts Survival
the Cancer Therapy Advisor take:
Baseline and post-chemotherapy neutrophil-lymphocyte ratio (NLR) change are potential biomarkers for overall survival in patients with advanced pancreatic cancer undergoing chemotherapy, according to a study published in the Annals of Surgical Oncology.
Researchers at the Fudan University Shanghai Cancer Center in China retrospectively examined 403 patients who had undergone chemotherapy for advanced pancreatic adenocarcinoma from 2002 to 2013. They wanted to determine the prognostic role of NLR in these patients.
The researchers performed univariate and multivariate analyses in order to identify clinicopathological predictors of overall survival that included baseline NLR and post-chemotherapy NLR.
They found that both baseline NLR and post-chemotherapy NLR change were independent prognostic factors in overall survival.
NLR of 3.1 or greater before chemotherapy as well as NLR post-chemotherapy change were both significantly associated with distant metastasis, serum CA19-9 levels and serum albumin levels.
NLR change is a potential biomarker for survival in advanced pancreatic cancer.
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- Arrival of CAR-T Immunotherapy Raise Hopes for Treatment and Anxieties About Costs
- St John's Wort and Cancer
- Osimertinib Granted Breakthrough Therapy Designation as First-line Treatment for EGFR-positive NSCLC
- Radiation Therapy Increases 5-year Rate of Cardiac Events in Small-cell Lung Cancer
- Pazopanib: Where Does It Stand as Adjuvant Therapy in Localized RCC?
- NSCLC: Researchers Identify Socioeconomic Factors Linked to Overall Survival
- Savolitinib Plus Gefitinib May Be Effective in EGFR-Mutant, MET-amplified NSCLC
- Maintenance Pazopanib Provides PFS, not OS, Benefit in Small-cell Lung Cancer
- Pembrolizumab Plus Pemetrexed, Carboplatin Prolongs Survival in NSCLC
- Repeat T790M Testing Recommended for TKI-resistant Patients With NSCLC