GEMOXEL Regimen May Be Better Than Standard Therapy for Pancreatic Cancer

Share this content:
GEMOXEL regimen may be safe, more efficient than standard therapy for metastatic pancreatic cancer.
GEMOXEL regimen may be safe, more efficient than standard therapy for metastatic pancreatic cancer.

The GEMOXEL (gemcitabine, oxaliplatin, capecitabine) regimen may be safe and more efficient than standard therapy with gemcitabine alone in the treatment of patients with metastatic pancreatic cancer, a study published in the journalCancer Chemotherapy and Pharmacology has shown.

For this phase II study, researchers sought to compare the activity and safety of the GEMOXEL regimen versus gemcitabine alone in patients with metastatic pancreatic cancer.

Researchers enrolled 67 patients and randomly assigned them 1:1 to receive gemcitabine 1,000mg/m2 IV on days 1, 8, 15, and 22, oxaliplatin 100mg/m2 IV on day 2, and capecitabine 1,500mg/m2/day on days 1-14 of each 21-day cycle or gemcitabine alone.

All participants received gemcitabine weekly for 7 consecutive weeks followed by 1-week rest for the first 8 weeks. Then, gemcitabine was continued on days 1, 8, and 15 every 28 days.

RELATED: New, Less Aggresssive Guidelines for Pancreatic Cysts

Results showed that the median progression-free survival was 6.8 months (95% CI: 5.3-7.3) and 3.7 months (95% CI: 2.9-4.7) in the GEMOXEL and gemcitabine arms, respectively (P < 0.001).

Researchers found that median overall survival was 11.9 months (95% CI: 10.6-12.9) in the GEMOXEL arm and 7.1 months (95% CI: 5.5-9.1) in the gemcitabine arm (P < 0.001).

In regard to safety, toxicities were more severe with GEMOXEL than gemcitabine alone, but still tolerable. No patients experienced grade 4 adverse events.

Reference

  1. Petrioli R, Roviello G, Fiaschi AI, et al. Gemcitabine, oxaliplatin, and capecitabine (GEMOXEL) compared with gemcitabine alone in metastatic pancreatic cancer: a randomized phase II study. Cancer Chemother Pharmacol. 2015;75(4):683-690.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters