Quality of Life Outcomes Differ Among Patients with Low-Grade Prostate Cancer

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Urinary and sexual health-related quality of life outcomes were worse for low-grade prostate cancer patients who underwent radical prostatectomy.
Urinary and sexual health-related quality of life outcomes were worse for low-grade prostate cancer patients who underwent radical prostatectomy.

No differences in mental health outcomes were observed between patients with low-risk prostate cancer who received active surveillance or radical prostatectomy, but urinary and sexual health-related quality of life (HRQoL) outcomes were worse for patients who underwent radical prostatectomy for up to 3 years, a new prospective study published online early in the journal Cancer has shown.

For the study, researchers sought to longitudinally compare HRQoL in a prospective, contemporary, and racially diverse cohort of patients with low-risk prostate cancer who underwent radical prostatectomy or active surveillance.

Researchers surveyed 288 patients no older than 75 years of age with low-risk prostate cancer who underwent radical prostatectomy and 77 who underwent active surveillance for initial disease management. Participants were followed for 3 years.

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Results showed that patients in the surgery group had significantly worse sexual function, sexual bother, and urinary function compared with patients in the active surveillance group; however, there were no significant differences in mental health outcomes between groups at 1 year.

Reference

  1. Jeldres C, Cullen J, Hurwitz LM, et al. Prospective quality-of-life outcomes for low-risk prostate cancer: active surveillance versus radical prostatectomy. Cancer. 2015. [Epub ahead of print]. doi: 10.1002/cncr.29370.

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