In mRCC, Targeted Therapies Show Activity Following PD-1/PD-L1 Blockade

Share this content:
Researchers sought to evaluate efficacy of targeted therapy after PD-1/PD-L1 blockade in patients with metastatic renal cell carcinoma.
Researchers sought to evaluate efficacy of targeted therapy after PD-1/PD-L1 blockade in patients with metastatic renal cell carcinoma.

Both vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor (VEGFR) inhibitors and mammalian target of rapamycin (mTOR) inhibitors demonstrate antitumor activity following programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) blockade in patients with metastatic renal cell carcinoma (mRCC), a new study published online ahead of print in the European Journal of Cancer has shown.1

Results showed that median time to treatment failure on subsequent targeted therapy was 6.6 months and 1-year and 2-year overall survival from the initiation of subsequent targeted therapy was 58% (95% CI: 41-72) and 36% (95% CI: 18-54), respectively.

For the study, researchers sought to evaluate the efficacy of targeted therapy after PD-1/PD-L1 blockade in patients with mRCC.

RELATED: Sunitinib in a 2/1 Schedule Safer for mRCC, Another Study Suggests

The medical records of 99 patients who were treated with investigational PD-1 or PD-L1 pathway immunotherapy were analyzed to assess median time to treatment failure and overall survival after initiation of subsequent targeted therapy.

Of those 99, 56 patients received subsequent targeted therapy, 44 of which received VEGF/VEGFR inhibitors and 12 received mTOR inhibitors. Targeted therapy was administered as second-line, third-line, or beyond third-line in 16%, 43%, and 41% of patients who had received PD-1/PD-L1 monoclonal antibodies.

Reference

  1. Albiges L, Fay AP, Xie W, et al. Efficacy of targeted therapies after PD-1/PD-L1 blockade in metastatic renal cell carcinoma [published online ahead of print September 5, 2015]. Eur J Cancer. doi: 10.1016/j.ejca.2015.08.017.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs

Sign Up for Free e-newsletters