Reduced Target Volume Significantly Reduces Late Toxicities in Extremity Sarcoma
Significant reduction of late toxicities in extremity soft tissue sarcoma treated with preoperative image-guided radiation therapy.
According to a recent study published in the Journal of Clinical Oncology, researchers have found that there is a significant reduction of late toxicities in patients with extremity soft tissue sarcoma (STS) who were treated with preoperative image-guided radiation therapy (IGRT) to a reduced target volume.
For the multicenter, prospective phase II study, researchers sought to assess late toxicities in patients with STS treated with preoperative IGRT to a reduced target volume. Researchers enrolled 98 patients and assigned 12 to receive IGRT with chemotherapy (cohort A) and 86 to receive IGRT without chemotherapy (cohort B) followed by limb-sparing resection.
Cohort A was closed prematurely, and therefore only 79 patients from Cohort B were evaluable. Results showed that at a median follow-up of 3.6 years, five patients did not undergo surgery due to disease progression and five had local in-field treatment failures.
RELATED: Trabectedin Continuation vs. Interruption in Soft-Tissue Sarcoma
At 2 years, 10.5% of the evaluable 57 patients assessed for late toxicities experienced at least one grade ≥2 toxicity compared with 37% of patients reported in the National Cancer Institute of Canada SR2 study in which patients received preoperative radiation therapy without IGRT (P < 0.001).
The findings suggest that the target volumes used in this study are appropriate for patients with extremity STS receiving IGRT.
- Wang D, Zhang Q, Eisenberg BL, et al. Significant reduction of late toxicities in patients with extremity sarcoma treated with image-guided radiation therapy to a reduced target volume: results of Radiation Therapy Oncology Group RTOG-0630 Trial. J Clin Oncol. 2015. [Epub ahead of print]. doi: 10.1200/JCO.2014.58.5828.