POPULAR SECTIONS

TREATMENT REGIMENS DRUG INFO MEDICAL CALCULATORS PUBLISHERS ALLIANCE VIDEOS CME

Use of an enzyme inhibitor in treating pancreatic cancer

Share this article:

Resistance to chemotherapy is one of the greatest challenges in pancreatic cancer treatment. However, US researchers have found that inhibiting the enzyme TAK-1 can overcome this.

Once the researchers had developed a drug to inhibit the enzyme, they tested it in combination with gemcitabine, oxaliplatin and SN-38 (a metabolite of irinotecan). The TAK-1 inhibitor increased the sensitivity of pancreatic cancer cells in culture to all three anticancer drugs, enabling the use of doses that were up to 70 times lower than those required in controls to kill the same number of cancer cells.

Further study in mice showed that combining the TAK-1 inhibitor with very low doses of gemcitabine resulted in a 78 per cent reduction in tumour volume and prolonged survival. Use of gemcitabine alone against the cancer in mice was ineffective.

Melisi D, Xia Q, Abbruzzese JL et al. TGF-beta-activated kinase 1 (TAK1) is an in vivo druggable target for reverting pancreatic cancer chemoresistance. Abstract O-1002. Eur J Cancer Suppl 2009;7(2):87

Originally published in the December 2009 edition of MIMS Oncology & Palliative Care.

Share this article:
You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Community Poll

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs