A 71-Year-Old Male Presents with Androgen-Deprivation Therapy (ADT) Resistance

By Michael A. Maccini, MD, and E. David Crawford, MD


Mr. G is an active 71 year old male referred to our second opinion clinic in June 2011 due to persistently elevated prostate-specific antigen (PSA) levels following robotic radical prostatectomy 2 months prior.

Surgical pathology was notable for Gleason grade 4 + 3 = 7 prostate cancer (pT2c) with negative surgical margins ...