AACR 2018

Check-Mate 141 Results: Nivolumab Improved OS in Patients With Recurrent or Metastatic Head and Neck Cancer

Check-Mate 141 Results: Nivolumab Improved OS in Patients With Recurrent or Metastatic Head and Neck Cancer

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Not all patients who received nivolumab, however, had improved PFS.

Olaparib May Not Improve Overall Survival vs Chemotherapy in Breast Cancer

Olaparib May Not Improve Overall Survival vs Chemotherapy in Breast Cancer

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At the time of final analysis, 192 of 302 patients had died.

BLU-667 Promising in <i>RET</i>-Altered Solid Tumors

BLU-667 Promising in RET-Altered Solid Tumors

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Doses of at least 60 mg yielded tumor reductions of 2% to 70% among 25 of the 30 evaluated patients.

Pembrolizumab Before Radical Cystectomy: Safe and Effective in Urothelial Carcinoma

Pembrolizumab Before Radical Cystectomy: Safe and Effective in Urothelial Carcinoma

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One instance of grade 3 alanine aminotransferase elevation and 5 instances of reversible immune-related adverse events were observed.

Adjuvant Pembrolizumab Reduces Risk of Recurrence in Stage III Melanoma

Adjuvant Pembrolizumab Reduces Risk of Recurrence in Stage III Melanoma

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Improvement in RFS was seen regardless of PD-L1 status.

CTCs May Not Have Genetic Changes Found in Primary Lung Tumors

CTCs May Not Have Genetic Changes Found in Primary Lung Tumors

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At surgery, blood samples were taken from 163 patients; whole genome sequencing and whole exome signaling were performed on detected CTCs.

Rotavirus Vaccine May Overcome Immunotherapy Resistance

Rotavirus Vaccine May Overcome Immunotherapy Resistance

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Researchers infected various tumor cell lines with anti-rotavirus vaccines confirmed to be PRR agonists.

Highly Selective, First-in-Class CDK4 Inhibitor Promising in Ovarian Cancer

Highly Selective, First-in-Class CDK4 Inhibitor Promising in Ovarian Cancer

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Mice treated with 2-94 had few or no signs of lymphopenia or neutropenia, common adverse events associated with palbociclib.

Tumor Cell Lysate Vaccine Shows Promise

Tumor Cell Lysate Vaccine Shows Promise

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Antigen-specific T cells increased in frequency in vaccinated mice.

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