ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

ANZEMET INJECTION
Nausea
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

ANZEMET INJECTION Rx

Generic Name and Formulations:
Dolasetron mesylate 20mg/mL; IV inj.

Company:
Sanofi U.S.

Therapeutic Use:

Indications for ANZEMET INJECTION:

Prevention and treatment of post-op nausea & vomiting.

Adult:

Give by IV inj, either undiluted 100mg over 30 seconds or diluted to 50mL and infused over up to 15 mins. ≥16yrs: Prevention: 12.5mg given as a single dose about 15 mins before stopping anesthesia. Treatment: 12.5mg as soon as needed.

Children:

May give by IV inj as in adult dose, or may be mixed into apple or apple-grape juice and taken orally (timing and doses are different; see full labeling). <2yrs: not established. 2–16yrs: Prevention: 0.35mg/kg IV (max 12.5mg) given as single dose about 15 mins before stopping anesthesia; or, 1.2mg/kg (max 100mg) mixed into apple or apple-grape juice and taken orally within 2hrs before surgery. Treatment: 0.35mg/kg IV as soon as needed.

Contraindications:

Inj soln administered by IV: Prevention of nausea & vomiting associated with emetogenic cancer chemotherapy, including initial and repeat courses in adults and children.

Warnings/Precautions:

Increased risk of developing QTc, PR and QRS interval prolongation. Avoid in patients with congenital QT syndrome, hypokalemia, hypomagnesemia, complete heart block or risk of (unless paced). Correct electrolyte imbalances prior to therapy. Monitor ECG periodically. CHF. Bradycardia. Pre-existing conduction abnormalities and underlying structural heart disease. Sick sinus syndrome. Atrial fibrillation with slow ventricular response. Recent MI. Renal impairment. Elderly. Pregnancy (Cat.B). Nursing mothers.

See Also:

ANZEMET

Pharmacological Class:

Selective 5-HT3 receptor antagonist.

Interactions:

Caution with drugs which can prolong ECG intervals (eg, verapamil, flecainide, quinidine), diuretics, and with cumulative high-dose anthracycline therapy. Serotonin syndrome possible with concomitant serotonergic drugs (eg, SSRIs, SNRIs). Potentiated by cimetidine, atenolol (IV dolasetron). Antagonized by rifampin.

Adverse Reactions:

Headache, dizziness, pain, fatigue, diarrhea, bradycardia, tachycardia, dyspepsia, chills/shivers, ECG changes, 2nd or 3rd-degree AV block; serotonin syndrome (discontinue if occurs).

How Supplied:

Tabs—5; Single-use vials (100mg/5mL)—1; Single-use vials (12.5mg/0.625mL)—6; Multidose vial (500mg/25mL)—1


Data provided by MPR.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs