ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

ARGATROBAN
Miscellaneous hematological agents
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

ARGATROBAN Rx

Generic Name and Formulations:
Argatroban 250mg/2.5mL; soln for IV infusion after dilution.

Company:
GlaxoSmithKline

Therapeutic Use:

Indications for ARGATROBAN:

Prophylaxis and treatment of thrombosis in adults with heparin-induced thrombocytopenia (HIT). Anticoagulation in adults with or at risk of HIT undergoing percutaneous coronary intervention (PCI).

Adult:

Give by IV infusion. HIT: discontinue heparin and obtain baseline aPTT. Initially 2mcg/kg/min; check aPTT 2hrs after starting; titrate to 1.5–3x baseline aPTT (max 100secs); max 10mcg/kg/min. PCI: give 350mcg/kg bolus by large bore IV line over 3–5mins, then initiate infusion of 25mcg/kg/min. Check ACT 5–10mins after bolus; titrate based on activated clotting time (ACT) to therapeutic ACT of 300–450secs (see full labeling). Hepatic impairment: reduce dose and titrate carefully; see full labeling. Conversion to oral anticoagulants: see full labeling.

Children:

Not established.

Contraindications:

Major bleeding.

Warnings/Precautions:

Increased bleeding risk (eg, severe hypertension, recent lumbar puncture, spinal anesthesia, major surgery, bleeding disorders, GI lesions). Hepatic impairment. PCI: avoid high doses in significant hepatic disease or AST/ALT ≥3x ULN. Labor & delivery. Pregnancy. Nursing mothers.

Pharmacological Class:

Direct thrombin inhibitor.

Interactions:

Increased risk of bleeding with concomitant thrombolytics, warfarin, heparin, antiplatelets, GP IIb/IIIa blockers.

Adverse Reactions:

Bleeding, dyspnea, hypotension, fever, diarrhea, sepsis, cardiac arrest, chest pain, back pain, nausea, vomiting, headache.

Generic Availability:

YES

How Supplied:

Single-use vial—1


Data provided by MPR.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs