Synchronized Delivery of Proteasome and Bone Marrow Microenvironment Inhibitors in MM

Share this content:
Restricting MM cancer cells from making contact with the bone marrow microenvironment may be achieved through the delivery of inhibitors through nanoparticles.
Restricting MM cancer cells from making contact with the bone marrow microenvironment may be achieved through the delivery of inhibitors through nanoparticles.
The following article features coverage from the American Society of Hematology (ASH) 2018 meeting. Click here to read more of Cancer Therapy Advisor's conference coverage.

SAN DIEGO — Reversing bone marrow microenvironment (BMM)-induced drug resistance in multiple myeloma (MM) may rely on lipid nanoparticle drug delivery, according to an abstract from the 2018 American Society of Hematology (ASH) Annual Meeting and Exposition in San Diego, California.1 Researchers hypothesized that inhibiting the interaction between the bone marrow microenvironment and multiple myeloma cells through the simultaneous delivery of 2 drugs may be a promising approach.

Since the bone marrow microenvironment is thought to drive resistance to proteasome inhibitors and promote tumor growth, and "agents that inhibit the interaction between MM and BMM have been shown to resensitize MM cells to therapy," the researchers focused on this pathway.

They looked at the nanoparticle drug delivery of bortezomib (BTZ) and ROCK-inhibitor (Y-27632), and discovered this route of delivery inhibited PI3K and MAPK signaling better compared with free bortezomib.

In addition, the synchronized delivery of bortezomib and Y-27632 using PSGL-1-targeted nanomedicine delayed tumor progression and prolonged survival in multiple myeloma significantly better than all other controls in the trial, they noted.

“Altogether, our data demonstrate the ability of PSGL-1-decorated LNPs to specifically target MM-BMM; to efficiently encapsulate and deliver drugs to tumor tissue; to overcome BMM-induced drug resistance in vitro and in vivo, to reduce tumor growth, and prolong overall survival,” the investigators concluded.

Disclosure: The investigators disclosed various ties to pharmaceutical companies in this abstract. For a full list of disclosures, please refer to the original study.

Read more of Cancer Therapy Advisor's coverage of the ASH 2018 meeting by visiting the conference page.

Reference

  1. Federico C, Muz B, Sun J, et al. Overcoming drug resistance in myeloma by synchronized delivery of therapeutic and bone marrow disrupting agents by nanoparticles targeting tumor-associated endothelium. Poster presentation at: American Society of Hematology 60th Annual Meeting & Exposition; December 1-4, 2018; San Diego, CA. Abstract 1931.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs